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Generation of An Inbred Miniature Pig Model of Retinitis Pigmentosa

A recent paper by Jason W. Ross, Juan P. Fernandez de Castro, Jianguo Zhao, Melissa Samuel, Eric Walters, Cecilia Rios, Patricia Bray-Ward, Bryan W. JonesRobert E. MarcWei Wang, Liang Zhou, Jennifer M. Noel, Maureen A. McCallPaul J. DeMarcoRandall S. Prather and Henry J. Kaplan describes the creation of a new model of retinal degenerative disease, specifically autosomal dominant retinitis pigmentosa in a miniature pig model, serving as an additional tool to study these diseases and therapeutic interventions.

The image above is a 5 channel dataset that appeared here of porcine retina labeled with antibodies to GABACRALBP and glutamate assigned to the red, green and blue color channels respectively.  The yellow and red dots at the top are alpha channels for rhodopsin and cone opsin respectively.

Categories: Moran Eye Center, Moran Eye Center Research, Notable papers.

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