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  1. Was Van Gogh Colorblind?

    A friend of mine (and amazing landscape/nature photographer) Jim Goldstein sent me a Tweet and pointed out simmering new conjecture in the art community that Vincent Van Gogh might have been color blind, specifically a protanope.  I seem to remember some discussion of this years ago, particularly given that one can rather nicely simulate both protanopia […]

    Aug 29, 2012 — Read more 1 Comment
  2. Notable Paper: Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

    How photoreceptor cells go through the process of cell death has been an outstanding question.  The authors of this paper by Yusuke Murakami, Hidetaka Matsumoto, Miin Roh, Jun Suzuki, Toshio Hisatomi, Yasuhiro Ikeda, Joan W. Miller, and Demetrios G. Vavvas have further defined the process and identified the receptor interacting protein kinase (RIP) pathway as a […]

    Aug 28, 2012 — Read more No Comments
  3. Foundation Fighting Blindness Announces $2.4 Million in Funding for Eight New Sight-Saving Research Projects

      Congratulations to our colleagues mentioned in the following press release.  We are always enthused to hear about funding and commitments to research, particularly when federal funding of research through traditional means has been getting harder to obtain.  This is where funding from private foundations like Foundation Fighting Blindness come through.  It enables work to […]

    Aug 22, 2012 — Read more No Comments
  4. Macular pigment imaging in AREDS2 participants: An ancillary study of AREDS2 subjects enrolled at the Moran Eye Center

      This study by Paul S. Bernstein, Faisal Ahmed, Aihua Liu, Susan Allman, Xiaoming Sheng, Mohsen Sharifzadeh, Igor Ermakov, and Werner Gellermann in IOVS examined the macular pigment in AREDS2 patients.  AREDS2 is a randomized, placebo-controlled study designed to determine whether supplementation with 10 mg of lutein and 2 mg of zeaxanthin per day can slow the rate […]

    Aug 17, 2012 — Read more No Comments
  5. Doctoral Dissertation Defenses: Scott Lauritzen and James Tucker

    Congratulations to Scott Lauritzen and James Tucker who successfully defended their dissertations earlier this year at the Moran Eye Center.  Scott will be staying with the Marclab for a postdoc while James will be returning to his medical school class to finish out his clinical years.  More pics from the dissertation defenses and after party […]

    Aug 16, 2012 — Read more No Comments
  6. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells

    This is an important issue for anyone involved in using murine models of retinal degeneration.  It turns out that contamination of Rd8 mutation in the B6 mice is more wide spread than the C57BL/6N mice.  Labs worldwide are going to have to reassess their data due to this mutation and all reviewers will ask about this […]

    Aug 9, 2012 — Read more No Comments
  7. Undersized Dendritic Arborizations in Retinal Ganglion Cells of the rd1 Mutant Mouse: A Paradigm of Early Onset Photoreceptor Degeneration

    This paper by Devid Damiani, Elena Novelli, Francesca Mazzoni and Enrica Strettoi documents continued negative plasticity in retina by examining ganglion cells in the rd1 mouse.  The rd1 mouse is one of many models of retinal degenerative disease, in this case as an autosomal recessive retinal degenerative disease.  This work gets at the remodeling issue […]

    Aug 8, 2012 — Read more No Comments
  8. Long-Term Characterization of Retinal Degeneration in rd1 and rd10 Mice Using Spectral Domain Optical Coherence Tomography

    This study by Mark E. Pennesi, Keith V. Michaels, Sienna S. Magee, Anastasiya Maricle, Sean P. Davin, Anupam K. Garg, Michael J. Gale, Daniel C. Tu, Yuquan Wen, Laura R. Erker, and Peter J. Francis documents the use of SD-OCT as a robust, non-invasive method for monitoring retinal changes in vivo in rodent models of retinal degeneration. […]

    Aug 6, 2012 — Read more No Comments
  9. Doctoral Dissertation Defense: Crystal Sigulinsky

    Congratulations to Dr. Crystal Sigulinsky on a successful defense to her dissertation, “Defining the relationship between the homeobox gene Vsx2 and extrinsic signaling in the regulation of retinal progenitor cell properties”.

    Aug 2, 2012 — Read more No Comments
  10. Metabolic Differentiation In The Embryonic Retina

    Michalis Agathocleous, Nicola K. Love, Owen Randlett, Julia J. Harris, Jinyue Liu, Andrew J. Murray and William A. Harris have published a very interesting story on proliferating cells of the Xenopus laevis retina that documents aerobic glycolysis rather than oxidative phosphorylation.  Historically, this shift in metabolism was termed the Warburg effect where it was originally described in […]

    Aug 1, 2012 — Read more No Comments