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  1. Foundation Fighting Blindness Has A New Blog, Eye On the Cure

    It looks like Foundation Fighting Blindness (FFB) has a new blog, Eye On the Cure with posts from Dr. Stephen Rose, Foundation Fighting Blindess’s chief research officer.  Steve will post perspectives on retinal research and other related news as well as posts from the road as he travels on research trips as well as covering vision [...]

    Mar 25, 2012 — Read more No Comments

  2. Review: Defective Trafficking of Rhodopsin and Its Role In Retinal Degenerations

    This is a great review paper on the role of rhodopsin trafficking and its influence on retinal degenerative disease by TJ Hollingsworth and Alecia Gross.  Rhodopsin delocalization in rod photoreceptors has been recognized for some time as one of the first indications of retinal photoreceptor cell stress in retinal degenerative diseases, so I was intrigued [...]

    Mar 15, 2012 — Read more No Comments

  3. Seminar: Bärbel Rohrer, Ph.D. “Sublytic Complement Activation in Age-Related Macular Degeneration”

    On Tuesday, March 20, 2012 from 4:00 – 5:00pm, Bärbel Rohrer, Ph.D. will be delivering a talk on “Sublytic Compliment Activation in Age-Related Macular Degeneration” at the Eccles Institute of Human Genetics auditorium on the University of Utah campus. Refreshments will be provided after the seminar for socialization. Faculty Host: Bryan William Jones, Ph.D. Questions?  Leave [...]

    Mar 12, 2012 — Read more No Comments

  4. Pseudoexfoliation

    This image demonstrates pseudo-exfoliation syndrome of the lens capsule.  

    Mar 3, 2012 — Read more No Comments

  5. Dysmorphic Photoreceptors in a P23H Mutant Rhodopsin Model of Retinitis Pigmentosa Are Metabolically Active and Capable of Regenerating to Reverse Retinal Degeneration

    This paper (and the cover article) is the result of a collaborative effort between Damian C. Lee, Felix R. Vazquez-Chona, W. Drew Ferrell, Beatrice M. Tam, Bryan W. Jones, Robert E. Marc, and Orson L. Moritz.

    Feb 29, 2012 — Read more No Comments

  6. 100 Papers You Should Read: Receptive Field Organization of the S-Potential

    This paper, the sixth in the 100 papers you should read in vision science category by Alan L. Norton, Henk Spekreijse, Myron L. Wolbarsht and Henry G. Wagner in 1968 examined the receptive fields of S-potentials in the retina of carp.

    Feb 24, 2012 — Read more No Comments

  7. Retinal Half Mosaic

    This beautiful image is another by Gabriel Luna out of Steve Fisher and Geoff Lewis’s retinal cell biology group at UC Santa Barbara Neuroscience Research Institute that shows a small mosaic of the outer plexiform layer in mouse retina stained with anti-Calbindin D (green; horizontal cells) PNA (red; cone terminals) and GFP for bipolar cells (blue).  I love the regular order [...]

    Feb 19, 2012 — Read more No Comments

  8. Notable Paper: Gene Therapy Rescues Photoreceptor Blindness in Dogs and Paves The Way for Treating Human X-linked Retinitis Pigmentosa

    This paper in PNAS by William A. Beltran, Artur V. Cideciyan, Alfred S. Lewin, Simone Iwabe, Hemant Khanna, Alexander Sumaroka, Vince A. Chiodo, Diego S. Fajardo, Alejandro J. Román, Wen-Tao Deng, Malgorzata Swider, Tomas S. Alemán, Sanford L. Boye, Sem Genini, Anand Swaroop, William W. Hauswirth, Samuel G. Jacobson and Gustavo D. Aguirre is a continuation [...]

    Feb 8, 2012 — Read more No Comments

  9. Generation of An Inbred Miniature Pig Model of Retinitis Pigmentosa

    A recent paper by Jason W. Ross, Juan P. Fernandez de Castro, Jianguo Zhao, Melissa Samuel, Eric Walters, Cecilia Rios, Patricia Bray-Ward, Bryan W. Jones, Robert E. Marc, Wei Wang, Liang Zhou, Jennifer M. Noel, Maureen A. McCall, Paul J. DeMarco, Randall S. Prather and Henry J. Kaplan describes the creation of a new model of retinal degenerative disease, specifically autosomal dominant retinitis pigmentosa in a miniature pig model, [...]

    Feb 7, 2012 — Read more No Comments

  10. Metabolomic Eye Wins Science and Engineering Visualization Challenge

    The image that is used for the avatar here on Webvision has been awarded first place in the journal Science and the National Science Foundation‘s Science and Engineering Visualization Challenge for 2011 (video with interviews here).

    Feb 5, 2012 — Read more 2 Comments

  11. Iris Tumor Goniometer

    Iris tumors are fairly common and have been featured here on Webvision before.  Most “tumors” are actually cysts or benign nevi, but malignant melanomas also can occur.  

    Feb 1, 2012 — Read more No Comments

  12. 100 Papers You Should Read: Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

    This is the fifth paper in the category, 100 Papers You Should Read (in vision science). This paper in the journal Science by Jeremy Nathans, Darcy Thomas and David Hogness in the genetics of human vision is a landmark paper in our understanding of how color vision works.

    Jan 31, 2012 — Read more No Comments

  13. Jumping Spiders Use Image Defocusing For Depth Perception

    A study out in today’s Science Magazine by Takashi Nagata, Mitsumasa Koyanagi, Hisao Tsukamoto, Shinjiro Saeki, Kunio Isono, Yoshinori Shichida, Fumio Tokunaga, Michiyo Kinoshita, Kentaro Arikawa and Akihisa Terakita proposes that jumping spiders at least, use image defocusing to provide depth perception.  Jumping spiders (Salticidae) are the largest family of spiders and have perhaps the best visual [...]

    Jan 26, 2012 — Read more 2 Comments

  14. Astrocyte pVHL and HIF-α Isoforms Are Required for Embryonic-To-Adult Vascular Transition In The Eye

    This paper from Toshihide Kurihara, Peter Westenskow, Tim Krohne, Edith Aguilar, Randy A. Johnson, and Marty Friedlander propose a model for the transition from embryonic to adult circulation in the eye  using a combinatorial gene deletion approach with over expression assays, examining astrocyte-targeted deletion of von Hippel-Lindau tumor suppressor (Vhl), hypoxia-inducible factor-αs (Hif-αs), and VEGF [...]

    Jan 13, 2012 — Read more No Comments

  15. Functional Activation of Glutamate Ionotropic Receptors in the Human Peripheral Retina

    This paper by Clairton F. de Souza, Michael Kalloniatis, Philip J. Polkinghorne, Charles N.J. McGhee, Monica L. Acosta examines glutamate receptors and their functional activation in the human retina.

    Jan 9, 2012 — Read more No Comments

  16. Webvision Year In Review

    2011 was a big year for Webvision.  We moved servers to a new MacPro, served up one million pages, underwent a major redesign in April by moving the database onto WordPress platform, and started the blog portion of Webvision in addition to the traditional chapter content that has made us so popular.

    Jan 6, 2012 — Read more No Comments

  17. Merry Christmas and Happy New Year, 2011

    Merry Christmas and Happy New Year to you from all of us at Webvision.  This image, a Christmas wreath created by Robert E. Marc is composed of 104 rod bipolar cell axonal fields from the world’s first complete connectome with synaptic level resolution.  Each bipolar cell in this field has been annotated from ultrastructural data [...]

    Dec 24, 2011 — Read more No Comments

  18. Activated Müller Glia

    Friend of Webvision, Peter Westenskow in the Friedlander Laboratory sent us this beautiful image of activated Müller glia in a stressed mouse eye.  You can see the scar in the photoreceptor layer towards the top of the image.  The mouse line is VLDLR -/-.  These mice exhibit aberrant neovascular tufts that invade the ONL and eventually [...]

    Dec 23, 2011 — Read more No Comments

  19. RD 2012: XVth International Symposium on Retinal Degeneration Announcement

    We just received program notice of the XVth International Symposium on Retinal Degeneration that will be held, July 16-20, 2012 Bad Gögging, Bavaria, Germany.

    Dec 12, 2011 — Read more No Comments

  20. Notable Paper: Acute vision in the giant Cambrian predator Anomalocaris and the origin of compound eyes

    Because knowing where we have come from with respect to the evolution of vision is so important, this paper by John R. Paterson, Diego C. García-Bellido, Michael S. Y. Lee, Glenn A. Brock, James B. Jago and Gregory D. Edgecombe gets our nod for a notable paper.  It does not hurt that I have a [...]

    Dec 7, 2011 — Read more No Comments

  21. Optic Nerve Head

    Another amazing image sent to us by Gabriel Luna out of the Steve Fisher and Geoff Lewis’s retinal cell biology group at UC Santa Barbara Neuroscience Research Institute.  This image is of the optic nerve head of a normal mouse retina displaying the “glial tubes” formed by the astrocytic network (anti-GFAP; red).  Anti-GFP (green) and anti-Collagen IV (blue) which [...]

    Dec 1, 2011 — Read more No Comments

  22. Bärbel Rohrer, Ph.D. Stanley H. and Theodora L. Feldberg Chair in Ophthalmology

    We here at Webvision are deliriously happy to report that our good friend and colleague, Bärbel Rohrer was just appointed the Stanley H. and Theodora L. Feldberg Chair in Ophthalmology at Medical University of South Carolina.  Many congratulations to her and we’ll look forward to congratulating her in person when she comes to visit us [...]

    Nov 23, 2011 — Read more No Comments

  23. Retinal Pigment Epithelium Cultures

    Friend of Webvision, Peter Westenskow in Marty Friedlander’s laboratory sent along this gorgeous image of retinal pigment epithelium (RPE) cells differentiating from induced pluripotent stem cells.  

    Nov 19, 2011 — Read more No Comments

  24. Metabolic Profiling of Activated Retinal Glia

    Presented at the Society for Neuroscience meetings in Washington, D.C. by Felix Vazquez-Chona, William Drew Ferrell, Ed Levine, Bryan William Jones and Robert E. Marc.  Full size poster can be seen here.

    Nov 18, 2011 — Read more No Comments

  25. Keratoprosthesis

    This image is from a patient has a keratoprosthesis or artificial cornea.  Photograph was made by James Gilman of the Moran Eye Center using a sclerotic scatter illumination with a Zeiss photo slitlamp and a Nikon D-1X camera.  

    Nov 17, 2011 — Read more No Comments