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What It Looks Like To Be Colorblind, Part II


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We’ve linked to posts before about what it looks like to people who are colorblind complete with animated gifs, but there is a new resource of gifs from the U.K.’s Clinic Compare that have a more film like quality and include a wider variety of color blindness forms.  We include a number of them below including green-blind/Deuteranopia, blue cone monochromacy, red-weak protanomaly, blue-blind/tritanomaly, green-weak deuteranomaly, monochromacy/acrhomatopsia, red-blind protanopia, and red-weak protanomaly.

gifs are rather large, so give them time to upload.

ht: @boingboing for the link.

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Categories: Interesting.

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TRPV4 Regulates Calcium Homeostasis, Cytoskeletal Remodeling, Conventional Outflow and Intraocular Pressure

Krizaj glaucoma

Glaucoma is the main cause of irreversible blindness in the world. In most common types of the disease, the optic nerve is damaged by an increase in intraocular pressure (IOP) which blocks fluid drainage through canals in the eye. There is currently no cure, however, the disease can be treated by lowering IOP. Unfortunately, all IOP-lowering drugs that in the market today target the secondary drainage pathway which mediates only 5-15% of fluid outflow. Therefore, the main goal in glaucoma research has been to identify targets in the primary outflow pathway mediated through the trabecular meshwork tissue. David Krizaj’s group at the Moran Eye Institute (University of Utah School of Medicine) has done just that.

In a paper just published in Scientific Reports, they identify TRPV4, a mechanosensitive ion channel, as the main trabecular target of increased IOP. This highly collaborative project combined genetic, molecular, whole animal approaches with bioengineered nanoscaffold models of glaucoma and drug discovery to show that activation of the channel mimics the trabecular changes in glaucoma whereas elimination of the TRPV4 gene or systemic exposure to TRPV4 inhibitors protected mice from the disease. In collaboration with Glenn Prestwich’s group in Medicinal Chemistry at the University of Utah, the team synthesized new eye drops which lowered IOP to levels seen in control mice. By targeting the primary outflow pathway, this study promises to bring new, effective cures that complement current glaucoma treatment. The primary authors of the study are Dr. Dan Ryskamp, Amber Frye and Dr. Tam Phuong.

Categories: Moran Eye Center, Moran Eye Center Research, Notable papers, Retinal Disease.

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Seminar: The 411 On Subretinoid Deposits In Age-Related Degeneration

Seminar Flyer - Curcio

Christine Curcio, Professor of Ophthalmology at University of Alabama At Birmingham School of Medicine will be delivering a seminar on “The 411 on subretinoid deposits in age-related degeneration” on Wednesday, June 8th at 12:00 Noon in the Moran Eye Center auditorium.

Categories: Seminar.

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Please Touch The Art

Please Touch The Art is a short film about Andrew Myers, an artist who creates tactile art for the blind and visually impaired.  Andrew got his start producing the art as a surprise for his friend George Wurzel and has continued to work in the medium designed to help the blind and low vision community participate in the art experience.

Hat tip to Lori Dorn of Laughing Squid for this post.

 

Categories: Interesting.

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Off To ARVO 2016

Porthole

We are off to ARVO 2016 in Seattle, Washington to participate in the largest gathering of vision scientists and ophthalmologists in the world.  It’s the annual meeting of researchers and clinicians presenting and discussing all things vision and ophthalmology.

If you are going to be at ARVO and want to meet up, leave us a comment here or send a Tweet to @Webvision1 and if you are on Twitter, be sure to use the #ARVO2016.

Look forward to seeing you there.

 

 

Categories: Uncategorized.

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Seminar: Calcium Homeostasis in Mammalian Rod and Cone Photoreceptors

Seminar Flyer - Kefalov

Vladimir Kefalov, Professor of Ophthalmology and Visual Sciences at Washington University in St. Louis will be delivering a seminar on “Calcium Homeostasis in Mammalian Rod and Cone Photoreceptors” on Wednesday, May 11th at 12:00 Noon in the Moran Eye Center auditorium.

Abstract: Calcium plays an important role in the function and health of photoreceptors. Calcium modulates the phototransduction cascade and controls the response sensitivity, response kinetics, and adaptation. Abnormal calcium homeostasis, associated with mutations in multiple phototransduction proteins, has also been suggested to cause retinal degeneration and blindness. This talk will present the results of our recent studies on the mechanisms for extruding calcium from mammalian photoreceptors. We have identified novel mechanisms for regulating calcium in both rods and cones. The implications of our findings for the function and survival of mammalian photoreceptors will also be addressed

Categories: Seminar.

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SciShow: How Different Animals and Insects Visually Process the World Around Them

This is a fun and pretty accurate Youtube video on how different animals (vertebrates and invertebrates) visually process the world.  There is so much to learn from the evolution of the eye and we here on Webvision are always happy to see basic science and the science of vision being communicated to the wider public.

Note: I first saw this on a Laughing Squid blog entry. Lori Dorn posts the best articles there.

Categories: Interesting Links.

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Basic science: Bedrock of progress

Basic science

 

There is an excellent editorial in the 25 March 2016 edition of Science Magazine from Francis Collins et. al. re-stating the NIH position on support for basic science.  This is important for anyone applying to the NIH for grants as well as those reviewing NIH grants as the central question should be: “How much will the proposed work advance understanding and progress in the field?”.

Categories: Funding Opportunities, Interesting.

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Faculty Opportunity Moran Eye Center

Moran Eye Center-Color-CR_1

 

The University of Utah Department of Ophthalmology and Visual Sciences invites applications for a full-time position at the level of Assistant/Associate Professor (commensurate w/experience) in the field of visual system function and or/disease. Successful candidates are expected to establish a strong research program funded by federal sources (NIH, NSF), to strengthen the current research carried out at the Moran Eye Institute as well as bring new areas of research into focus.

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Categories: Jobs.

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Store-Operated Calcium Entry In Müller Glia Is Controlled By Synergistic Activation Of TRPC And Orai Channels

JNeurosci cover_Vol36_Issue11_600

There is a new publication out in the Journal of Neuroscience (cover story) from Moran Eye Center scientists, Store-Operated Calcium Entry In Müller Glia Is Controlled By Synergistic Activation Of TRPC And Orai Channels authored by Tünde Molnár, Oleg YarishkinPeter Barabas, Anthony Iuso, Bryan William JonesRobert Marc, Tam Phuong, and David Krizaj.

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Categories: Moran Eye Center Research.

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Seminar: Photoreception In Fetal And Newborn Mice: Actions On Behavior And Vascular Patterning In The Eye

Seminar Flyer - Copenhagen.ppt

David Copenhagen, Professor of Ophthalmology and Physiology at University of California, San Francisco will be delivering a seminar on “Photoreception In Fetal And Newborn Mice: Actions On Behavior And Vascular Patterning In The Eye” on Wednesday, April 6th at 12:00 Noon in the Moran Eye Center auditorium.

Abstract:

Melanopsin-mediated photoreception in fetuses and young neonatal mice.
The newly discovered melanopsin-expressing photoreceptors in the eye are born around mid fetal gestation and well before rod and cone-mediated visual signaling emerges (~postnatal day 10) in mice. Our research focuses on understanding what visual functions are facilitated by photo activated melanopsin cells in fetal and neonatal animals. I will discuss also our studies directed toward elucidating signaling pathways activated by melanopsin cells in the eye.

Categories: Seminar.

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Seminar: Of Mice and Men, Between Bedside & Bench

Seminar Flyer - Tsang

Stephen H. Tsang, Associate Professor of Ophthalmology at Columbia University will be delivering a seminar on “Of Mice and Men: Between Bedside & Bench” on Wednesday, March 16th at 11:30am in the Moran Eye Center auditorium.  Stephen will be discussing the application of genome engineering in stem cells to study “three blind mice”.

Categories: Seminar.

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Seminar: Anterior and Posterior Segments of the eye: Hijacking Corneal Development and Novel Therapeutics for Retinal Regeneration

Seminar Flyer - Carroll

Lara Carroll, who works in the Bala Ambati laboratory will deliver a seminar on Anterior and Posterior Segments of the eye: Hijacking Corneal Development and Novel Therapeutics for Retinal Regeneration, on Wednesday, March 9th in the Moran Eye Center auditorium.

Abstract: Non-keratinized epithelium is essential for corneal transparency and vision. The molecular defects causing millions of patients worldwide to suffer from corneal surface disease are largely unknown. During my post-doc in Mario Capecchi’s lab, I found that conditional misexpression of HoxC8 in surface ectoderm caused differentiation of embryonic mouse corneal and conjunctival epithelium into keratinized skin-like epithelium. Expression of the corneal genes Pax6 and K12 was lost, whereas basal epithelial cells upregulated P63, a keratinocyte stem cell marker. My work is consistent with recent data demonstrating a Wnt signaling/Pax6/P63 corneal requirement for maintenance of adult corneal epithelium, and reveals additional molecular events that are likely essential for proper epithelial differentiation of the ocular surface during corneal development.

In the Ambati laboratory, we test methods for preserving and regenerating the inner retina following a variety of retinal assaults. We found that preventative therapy involving COMP-Ang1/Tie2 signaling stabilizes vascular beds and reduces ischemic damage in mice with retinal stroke and diabetic retinopathy. I am now focused on developing complementary strategies to improve preservation of the inner retina and reverse damage after it occurs.

Categories: Seminar.

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Why Do Goat Eyes Look The Way They Do?

There is a new Explorer special based on an article in the latest issue of National Geographic with Michael Stevens (@tweetsauce), Unlocking The Eyes that is well worth checking out. In the video above, Michael interviews Marty Banks and William Sprague about why many prey animals like goats have the eye anatomy they do. i.e., why are their eyes have horizontal pupils and why their eyes are positioned on the sides of their heads?

 

Categories: Evolution of Vision, Interesting, Interesting Links.

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Losing His Sight, This Photographer Chases the Light

This short video features the art of Steven Erra, a photographer who is losing his vision due to a retinal degenerative disease, yet is generating beautiful work by light painting.  Steven is a member of The Seeing With Photography Collective, a group of sight impaired artists who are making waves in the art world through their imagery and inspiring the work of both sighted and non-sighted photographers alike.

Categories: Art of Vision, Interesting.

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