Comments on: The retinal pigment epithelium http://webvision.med.utah.edu The Organization of the Retina and Visual System Fri, 14 Jun 2013 16:17:42 +0000 hourly 1 http://wordpress.org/?v=3.5.1 By: Gene Therapy Rescues Photoreceptor Blindness in Dogs and Paves The Way for Treating Human X-linked Retinitis Pigmentosa – Webvision http://webvision.med.utah.edu/book/part-ii-anatomy-and-physiology-of-the-retina/the-retinal-pigment-epithelium/#comment-48294 Gene Therapy Rescues Photoreceptor Blindness in Dogs and Paves The Way for Treating Human X-linked Retinitis Pigmentosa – Webvision Wed, 08 Feb 2012 13:01:13 +0000 http://155.100.105.205/?page_id=89#comment-48294 [...] authors past work has been in gene therapies in mouse and dog models where the defect was in the retinal pigment epithelium, this study presents data from a defect in photoreceptors, specifically mutations in the RPGR gene [...]

]]> By: StemCells, Inc. Announces Positive Preclinical Data for Its Human Neural Stem Cells Ability to Preserve Vision « Beyond the Dish http://webvision.med.utah.edu/book/part-ii-anatomy-and-physiology-of-the-retina/the-retinal-pigment-epithelium/#comment-44960 StemCells, Inc. Announces Positive Preclinical Data for Its Human Neural Stem Cells Ability to Preserve Vision « Beyond the Dish Mon, 30 Jan 2012 22:05:27 +0000 http://155.100.105.205/?page_id=89#comment-44960 [...] As photoreceptor cells respond to light, their outer membrane proteins suffer photo-oxidation. Retinal pigment epithelial cells phagocytose these defective photoreceptor outer membrane segments and recycle them, which [...]

]]> By: Bryan William Jones http://webvision.med.utah.edu/book/part-ii-anatomy-and-physiology-of-the-retina/the-retinal-pigment-epithelium/#comment-18444 Bryan William Jones Mon, 14 Nov 2011 00:38:31 +0000 http://155.100.105.205/?page_id=89#comment-18444 Hey Beth,

This is not really my area of expertise, but one might reason that hydroquinone could be metabolized to reactive intermediates that are then involved with covalent bonding events. If DNA/cell repair mechanisms were impaired by exposure, cell death may occur. Though I suspect that other mechanisms behind oxidative damage or reactive species are involved that may be quenched by molecular species that scavenge free radicals. I seem to remember some literature examining glutathione as a protective agent in some quinone toxicity studies. From: http://www.inchem.org/documents/hsg/hsg/hsg101.htm

“It is metabolized to p-benzoquinone and other oxidized products, and is detoxified by conjugation to monoglucuronide, monosulfate, and mercapturic derivatives.”

]]> By: Beth Snodgrass, CRA http://webvision.med.utah.edu/book/part-ii-anatomy-and-physiology-of-the-retina/the-retinal-pigment-epithelium/#comment-18400 Beth Snodgrass, CRA Sun, 13 Nov 2011 20:45:27 +0000 http://155.100.105.205/?page_id=89#comment-18400 I am an ophthamic photograper at Stanford & I am preparing a lecture on Hydroxycholorquine toxicity and correlating with Dr Marmor’s recent articles on toxicity screening. Would you speculate on the cause of HCQ toxicity? Could it be that the RPE immune response in suppressed by HCQ, or perhaps phagocytosis is accelerated?

Thank you!

]]> By: Notable Paper: Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2 – Webvision http://webvision.med.utah.edu/book/part-ii-anatomy-and-physiology-of-the-retina/the-retinal-pigment-epithelium/#comment-9309 Notable Paper: Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2 – Webvision Tue, 06 Sep 2011 15:24:45 +0000 http://155.100.105.205/?page_id=89#comment-9309 [...] to the nervous system, the retina included.  IRKs in the retina are found in Müller glia, retinal pigment epithelium and on neurons in retina, so are fundamental to retinal physiology.  However, their function and [...]

]]> By: Notable Paper: Increased Expression of Multifunctional Serine Protease, HTRA1, in Retinal Pigment Epithelium Induces Polypoidal Choroidal Vasculopathy – Webvision http://webvision.med.utah.edu/book/part-ii-anatomy-and-physiology-of-the-retina/the-retinal-pigment-epithelium/#comment-8167 Notable Paper: Increased Expression of Multifunctional Serine Protease, HTRA1, in Retinal Pigment Epithelium Induces Polypoidal Choroidal Vasculopathy – Webvision Sat, 20 Aug 2011 04:38:27 +0000 http://155.100.105.205/?page_id=89#comment-8167 [...] such as reading and driving.  Behind the retina is the choroid, the vascular layer of the eye.  Retinal pigment epithelium (RPE) is located between the retina and choroid.  Degenerative changes in the RPE and choroid target [...]

]]> By: Bryan William Jones http://webvision.med.utah.edu/book/part-ii-anatomy-and-physiology-of-the-retina/the-retinal-pigment-epithelium/#comment-4219 Bryan William Jones Sat, 02 Jul 2011 20:37:03 +0000 http://155.100.105.205/?page_id=89#comment-4219 Vitamin A like any vitamins must be obtained by through dietary intake. The RPE is involved in storage, metabolism and transport of vitamin A, but does not produce it. For a good reference, check out this paper by Flood et. al. http://www.iovs.org/content/24/9/1227.full.pdf and this paper for the effects of genetic defects on retinal pigment epithelium metabolism of vitamin A: http://www.ncbi.nlm.nih.gov/pubmed/12892646

]]> By: neela ramdass http://webvision.med.utah.edu/book/part-ii-anatomy-and-physiology-of-the-retina/the-retinal-pigment-epithelium/#comment-4137 neela ramdass Fri, 01 Jul 2011 04:15:58 +0000 http://155.100.105.205/?page_id=89#comment-4137 What is the function of the RPE with respect to Vitamin A. Does it produce vit A or just metabolise it?

]]> By: Stargardt’s Disease angiogram – Webvision http://webvision.med.utah.edu/book/part-ii-anatomy-and-physiology-of-the-retina/the-retinal-pigment-epithelium/#comment-3100 Stargardt’s Disease angiogram – Webvision Wed, 15 Jun 2011 13:01:58 +0000 http://155.100.105.205/?page_id=89#comment-3100 [...] ELOVL4 or PROM1.  The disease is a form of juvenile onset macular degeneration affecting the retinal pigmented epithelium (RPE).  The disease onset and progression is usually [...]

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