Comments on: Formation of Early Retinal Circuits in the Inner Plexiform Layer http://webvision.med.utah.edu The Organization of the Retina and Visual System Fri, 14 Jun 2013 16:17:42 +0000 hourly 1 http://wordpress.org/?v=3.5.1 By: Marla Feller and Kevin Ford http://webvision.med.utah.edu/book/part-vi-development-of-cell-types-and-synaptic-connections-in-the-retina/formation-of-early-retinal-circuits-in-the-inner-plexiform-layer/#comment-33204 Marla Feller and Kevin Ford Mon, 02 Jan 2012 19:44:59 +0000 http://155.100.105.205/?page_id=149#comment-33204 ACh released during retinal waves binds to nicotinic acetylcholine receptors on ganglion cells. These receptors are also ion channels , causing the ganglion cells to depolarize and fire action potentials. ACh is degraded by the enzyme
acetylcholine esterase, which terminates its action. During this early period of development, it is thought that ACh is released by starburst amacrine cells in not confined to synapses, but diffuses
throughout the extracellular space where it activates receptors on cells that are distal to the site of release. Syed et al. (2000) demonstrate that ACh released during waves activates a different type
of ACh receptor, muscarinic receptors, located on undifferentiated cells in the ventricular zone.

We have a revision to the chapter working its way through the editorial process. It addresses this point in more detail. It should be on the web very soon. It

]]> By: Joshua Ben-nun http://webvision.med.utah.edu/book/part-vi-development-of-cell-types-and-synaptic-connections-in-the-retina/formation-of-early-retinal-circuits-in-the-inner-plexiform-layer/#comment-32140 Joshua Ben-nun Fri, 30 Dec 2011 19:52:20 +0000 http://155.100.105.205/?page_id=149#comment-32140 Dear Dr Feller
Is it known how exactly any of the transmitters are attaching themselves to the ganglion cells to induce a recognized stimulation by the cell, and how it is eliminated afterwards. Is it the same basic Ach “synaptic transfer” mechanism or more sofisticated switching mechanism. I wonder.
could you possibly refer me to publications on this subject ?
Happy new year
Joshua Ben-nun MD

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