Skip to content

  1. TRPV4 Regulates Calcium Homeostasis, Cytoskeletal Remodeling, Conventional Outflow and Intraocular Pressure

    Glaucoma is the main cause of irreversible blindness in the world. In most common types of the disease, the optic nerve is damaged by an increase in intraocular pressure (IOP) which blocks fluid drainage through canals in the eye. There is currently no cure, however, the disease can be treated by lowering IOP. Unfortunately, all IOP-lowering drugs that in the market today target the […]

    Aug 17, 2016 — Read more No Comments
  2. Missense variant in CST3 Exerts Recessive Effect On Susceptibility to AMD

    There is an interesting paper out demonstrating that CST3 exerts a recessive effect on susceptibility to AMD.  Cystatin C is a potent inhibitor of cysteine proteinases expressed by many tissues and in the eye, it is highly expressed by the retinal pigment epithelium (RPE). The team led by Luminita Paraoan recently reported data identifying a polymorphism in the […]

    Sep 22, 2015 — Read more No Comments
  3. Notable Paper: Reproducibility in Science

    This article by C. Glenn Begley and John P.A. Ioannidis is not specifically vision related, but is more generally applicable to research integrity and is well worth a read, in particular the following paragraph: “What has shaken many in the field is not that investigators are unable to precisely reproduce an experiment. That is to […]

    Feb 25, 2015 — Read more No Comments
  4. Notable Papers: An Easier Way To Make Stem Cells?

    We’ve talked about work out of the RIKEN Institute before here on Webvision.  The work that comes out of there is clever and often unconventional.  The latest work from the RIKEN that seems to have gotten a bit of attention is two recent papers from Haruko Obokata and colleagues, here and here that discuss almost inconceivably simple […]

    Feb 15, 2014 — Read more No Comments
  5. Notable Paper: Ras Pathway Inhibition Prevents Neovascularization By Repressing Endothelial Cell Sprouting

    A new manuscript in the Journal of Clinical Investigation (on the cover) by Peter D. Westenskow, Toshihide Kurihara, Edith Aguilar, Elizabeth L. Scheppke, Stacey K. Moreno, Carli Wittgrove, Valentina Marchetti, Iacovos P. Michael, Sudarshan Anand, Andras Nagy, David Cheresh and Martin Friedlander at The Scripps Research Institute describes a new technique for treating aberrant growth of blood vessels in […]

    Nov 20, 2013 — Read more No Comments
  6. Notable paper: Lhx2 Balances Progenitor Maintenance With Neurogenic Output And Promotes Competence State Progression In The Developing Retina

    The Levine lab here at the Moran Eye Center has a new publication out in the Journal of Neuroscience and even scored the cover.  Specifically, the manuscript was authored by Patrick J. Gordon, Sanghee Yun, Anna M. Clark, Edwin S. Monuki, L. Charles Murtaugh, and Edward M. Levine.  The Levine team explored how multipotent retinal progenitor cells […]

    Jul 29, 2013 — Read more No Comments
  7. Notable Paper: Tuning The Electronic Absorption Of Protein-Embedded All-Trans-Retinal

    The pigments in retinal photoreceptor cells absorb varying wavelengths of light, but the central chromophore, the molecule that actually absorbs the photon is identical.  Its ability to tune the responsiveness comes from the association with other opsins giving an organism the ability to respond from the near ultraviolet all the way to far red.  Interestingly, […]

    Jul 18, 2013 — Read more No Comments
  8. Notable Paper: Paired-Pulse Plasticity In The Strength and Latency of Light-Evoked Lateral Inhibition to Retinal Bipolar Cell Terminals

    I’ve been doing some reading in plasticity recently and found this paper in the Journal of Neuroscience by Evan Vickers, Mean-Hwan Kim, Jozsef Vigh, and Henrique von Gersdorff published last summer that looks at short term plasticity in the Inner Plexiform Layer mediating light adaptation.  Working in goldfish (Carassius auratus auratus) retina (an amazing retina), Vickers et. al. […]

    Feb 21, 2013 — Read more No Comments
  9. Notable Paper: On Cone Bipolar Cell Axonal Synapses In The OFF Inner Plexiform Layer Of The Rabbit Retina

    This paper in the Journal of Comparative Neurology by  J. Scott Lauritzen, James R. Anderson, Bryan W. Jones, Carl B. Watt, Shoeb Mohammed, John V. Hoang and Robert E. Marc is another effort out of the Marc Laboratory For Connectomics that continues to define complete neural circuits to completeness. This paper is another elucidation of data from the first Rabbit Retinal Connectome volume (RC1) that reveals […]

    Jan 30, 2013 — Read more 1 Comment
  10. Notable Paper: Photomechanical Responses In Drosophila Photoreceptors

    This notable paper by Roger C. Hardie and Kristian Franze looks at phototransduction in the fruit fly, Drosophila melanogaster.  Drosophila melanogaster has a long history in vision research of informing our understanding of the biochemical processes involved in phototransduction going back almost 40 years to this paper.  However, the Hardie and Franze paper looks at transient receptor potential (TRP) […]

    Oct 17, 2012 — Read more No Comments
  11. Intrinsic Physiological Properties Of Rat Retinal Ganglion Cells With A Comparative Analysis

    This paper in the Journal of Neurophysiology by Raymond C S Wong, Shaun L Cloherty, Michael R Ibbotson and Brendan J O’Brien examined properties of retinal ganglion cells types that are conserved through mammalian species by looking at 16 morphologically defined rat and cat retinal ganglion cell types.  Their work demonstrates morphologically distinct retinal ganglion cell types […]

    Oct 11, 2012 — Read more No Comments
  12. Notable Paper: Molecular Analysis Of The Amphioxus Frontal Eye…

    We at Webvision have a fascination with the evolution of the eye and are always looking for interesting papers that help describe from where, how and when vision came.  This paper, Molecular analysis of the amphioxus frontal eye unravels the evolutionary origin of the retina and pigment cells of the vertebrate eye by Pavel Vopalenskya, Jiri […]

    Sep 19, 2012 — Read more No Comments
  13. Notable Paper: The Molecular Mechanism of Thermal Noise in Rod Photoreceptors

      Phototransduction is the process by which photon capture by opsins in photoreceptors is transduced into a neural signal.    However, there are limits on visual sensitivity that are imposed by thermal means as opposed to the photochemical mechanisms resulting in activation of the phototransduction cascade. The mechanism of this limit has long been a […]

    Sep 12, 2012 — Read more No Comments
  14. Notable Paper: Partial Rescue of Retinal Function in Chronically Hypoglycemic Mice

    This paper by Yumiko Umino, Nicolas Cuenca, Drew Everhart, Laura Fernandez-Sanchez, Robert B. Barlow and Eduardo Solessio examined late onset retinal degeneration in a model of diabetic retinopathy.  Specifically, this manuscript attempted to examine the impact on retinas from the Gcgr knockout mice with long term high dietary glucose to see if that rescues retinal structure […]

    Sep 5, 2012 — Read more No Comments
  15. Notable Paper: Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

    How photoreceptor cells go through the process of cell death has been an outstanding question.  The authors of this paper by Yusuke Murakami, Hidetaka Matsumoto, Miin Roh, Jun Suzuki, Toshio Hisatomi, Yasuhiro Ikeda, Joan W. Miller, and Demetrios G. Vavvas have further defined the process and identified the receptor interacting protein kinase (RIP) pathway as a […]

    Aug 28, 2012 — Read more No Comments
  16. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells

    This is an important issue for anyone involved in using murine models of retinal degeneration.  It turns out that contamination of Rd8 mutation in the B6 mice is more wide spread than the C57BL/6N mice.  Labs worldwide are going to have to reassess their data due to this mutation and all reviewers will ask about this […]

    Aug 9, 2012 — Read more No Comments
  17. Undersized Dendritic Arborizations in Retinal Ganglion Cells of the rd1 Mutant Mouse: A Paradigm of Early Onset Photoreceptor Degeneration

    This paper by Devid Damiani, Elena Novelli, Francesca Mazzoni and Enrica Strettoi documents continued negative plasticity in retina by examining ganglion cells in the rd1 mouse.  The rd1 mouse is one of many models of retinal degenerative disease, in this case as an autosomal recessive retinal degenerative disease.  This work gets at the remodeling issue […]

    Aug 8, 2012 — Read more No Comments
  18. Long-Term Characterization of Retinal Degeneration in rd1 and rd10 Mice Using Spectral Domain Optical Coherence Tomography

    This study by Mark E. Pennesi, Keith V. Michaels, Sienna S. Magee, Anastasiya Maricle, Sean P. Davin, Anupam K. Garg, Michael J. Gale, Daniel C. Tu, Yuquan Wen, Laura R. Erker, and Peter J. Francis documents the use of SD-OCT as a robust, non-invasive method for monitoring retinal changes in vivo in rodent models of retinal degeneration. […]

    Aug 6, 2012 — Read more No Comments
  19. Metabolic Differentiation In The Embryonic Retina

    Michalis Agathocleous, Nicola K. Love, Owen Randlett, Julia J. Harris, Jinyue Liu, Andrew J. Murray and William A. Harris have published a very interesting story on proliferating cells of the Xenopus laevis retina that documents aerobic glycolysis rather than oxidative phosphorylation.  Historically, this shift in metabolism was termed the Warburg effect where it was originally described in […]

    Aug 1, 2012 — Read more No Comments
  20. Store-Operated Channels Regulate Intracellular Calcium In Mammalian Rods

    This *very cool* paper in The Journal of Physiology (also featured in the F1000) by authors Tünde Molnar, Peter Barabas, Lutz Birnbaumer, Claudio Punzo, Vladimir Kefalov and David Krizaj examines mechanisms of cytosolic calcium levels in rod photoreceptor cells.

    Jul 20, 2012 — Read more 1 Comment
  21. Full-Length Axon Regeneration In The Adult Mouse Optic Nerve and Partial Recovery of Simple Visual Behaviors

    Friend of Webvision Yves Sauvé sent in this paper by Silmara de Lima, Yoshiki Koriyama, Takuji Kurimoto, Julia Teixeira Oliveira, Yuqin Yin, Yiqing Li, Hui-Ya Gilbert, Michela Fagiolini, Ana Maria Blanco Martinez, and Larry Benowitz that documents regeneration of the optic nerve in the adult mouse, a potentially substantial breakthrough in therapeutic recovery of vision lost through […]

    Jul 5, 2012 — Read more No Comments
  22. Functional and Anatomical Remodeling in Human Retinal Detachment

    This manuscript by Clairton F de Souza, Michael Kalloniatis, Philip J Polkinghorne, Charles N J McGhee and Monica L Acosta examined retinal remodeling in response to a form of retinal detachment.  Rhegmatogenous retinal detachment.  The authors describe the changes observed and note that retinal plasticity is acute and likely occurs quickly enough that it may explain persistent […]

    Jun 28, 2012 — Read more No Comments
  23. Microglia Sculpt Postnatal Neural Circuits In An Activity And Complement-Dependent Manner

    This very cool study by Dorothy P. Schafer, Emily K. Lehrman, Amanda G. Kautzman, Ryuta Koyama, Alan R. Mardinly, Ryo Yamasaki, Richard M. Ransohoff, Michael E. Greenberg, Ben A. Barres and Beth Stevens demonstrates how the immune system can participate in the circuitry of the developing mouse lateral genicular nucleus (LGN).

    Jun 11, 2012 — Read more No Comments
  24. Notable Paper: Network Deficiency Exacerbates Impairment in a Mouse Model of Retinal Degeneration

    This paper by Christopher W. Yee, Abduqodir H. Toychiev and Botir T. Sagdullaev examines the role that neural oscillations play in normal and pathological states.  In a neurodegenerative model of retinitis pigmentosa, the authors examined the activity of neural networks in the rd1 mouse model and compared that activity to the wild type.  

    Apr 1, 2012 — Read more No Comments
  25. Dysmorphic Photoreceptors in a P23H Mutant Rhodopsin Model of Retinitis Pigmentosa Are Metabolically Active and Capable of Regenerating to Reverse Retinal Degeneration

    This paper (and the cover article) is the result of a collaborative effort between Damian C. Lee, Felix R. Vazquez-Chona, W. Drew Ferrell, Beatrice M. Tam, Bryan W. Jones, Robert E. Marc, and Orson L. Moritz.

    Feb 29, 2012 — Read more No Comments