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  1. New Webvision Chapter: Retinal Degeneration, Remodeling and Plasticity

    We have a new Webvision chapter on Retinal Degeneration, Remodeling and Plasticity! Check it out here.

    Jun 1, 2015 — Read more No Comments
  2. Lasker/IRRF Report On Restoring Vision

    I participated in the Lasker/IRRF Initiative on Restoring Vision to the Blind in March 2014. It was a great session of research leaders working on various approaches to restore visual function lost by retinal degenerative disease. The purpose of the meeting was to identify the key issues hampering research progress and to develop innovative proposals […]

    Feb 27, 2015 — Read more No Comments
  3. Portrait Of Vision Scientist: Ann Morris

    Ann Morris from the University of Kentucky studies the zebrafish (Danio rerio).  In particular, she studies the ability of zebrafish retinas to regenerate following retinal injury or damage.  Retinal regeneration is an interesting phenomenon that mammalians seem to lack and yet zebrafish manage to do this despite having a retina that in many ways is far […]

    Jul 30, 2014 — Read more 1 Comment
  4. The Judgment Of Solomon

    I had the honor and privilege of attending a Lasker/IRRF Initiative’s plenary session on Restoring Vision to the Blind at Janelia Farm last month where Mr. Sanford D. Greenberg delivered an emotional and inspiring story of a time in his life where he lost his vision during his junior year at Columbia University.  The prospect of […]

    May 15, 2014 — Read more 2 Comments
  5. Notable Papers: An Easier Way To Make Stem Cells?

    We’ve talked about work out of the RIKEN Institute before here on Webvision.  The work that comes out of there is clever and often unconventional.  The latest work from the RIKEN that seems to have gotten a bit of attention is two recent papers from Haruko Obokata and colleagues, here and here that discuss almost inconceivably simple […]

    Feb 15, 2014 — Read more No Comments
  6. Interesting Article: Mechanism of RPE Cell Death in α-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux

    I ran across an interesting paper in PLOS One published back in March of 2012 by Parameswaran G. Sreekumar, Christine Spee, Stephen J. Ryan, Susan P. C. Cole, Ram Kannan and David R. Hinton.  This manuscript looks at a mechanism of retinal pigment epithelium (RPE) cell death with notable findings identifying therapeutic targets for disorders that involve the RPE cells. The […]

    Feb 9, 2014 — Read more No Comments
  7. Moran Eye Center International Outreach

    Here on Webvision, our goal is retinal education and even though Webvision is hosted here at the Moran Eye Center, we nevertheless try to include as much of the wider community as possible in posts and in content, though we will point out work that comes of of the Moran Eye Center from time to time. […]

    Jan 19, 2013 — Read more 1 Comment
  8. Full-Length Axon Regeneration In The Adult Mouse Optic Nerve and Partial Recovery of Simple Visual Behaviors

    Friend of Webvision Yves Sauvé sent in this paper by Silmara de Lima, Yoshiki Koriyama, Takuji Kurimoto, Julia Teixeira Oliveira, Yuqin Yin, Yiqing Li, Hui-Ya Gilbert, Michela Fagiolini, Ana Maria Blanco Martinez, and Larry Benowitz that documents regeneration of the optic nerve in the adult mouse, a potentially substantial breakthrough in therapeutic recovery of vision lost through […]

    Jul 5, 2012 — Read more No Comments
  9. Photovoltaic Retinal Prosthesis With High Pixel Density

    Retinas are complex systems and engineered rescues of vision loss through bionic means have to date been inelegant solutions.  Retinal bionic implants have historically not been successes due to some glaring problems including how to power them and how to get the appropriate current close enough to the cells to induce a response.  However, researchers […]

    May 15, 2012 — Read more No Comments
  10. Dysmorphic Photoreceptors in a P23H Mutant Rhodopsin Model of Retinitis Pigmentosa Are Metabolically Active and Capable of Regenerating to Reverse Retinal Degeneration

    This paper (and the cover article) is the result of a collaborative effort between Damian C. Lee, Felix R. Vazquez-Chona, W. Drew Ferrell, Beatrice M. Tam, Bryan W. Jones, Robert E. Marc, and Orson L. Moritz.

    Feb 29, 2012 — Read more No Comments
  11. Notable Paper: Gene Therapy Rescues Photoreceptor Blindness in Dogs and Paves The Way for Treating Human X-linked Retinitis Pigmentosa

    This paper in PNAS by William A. Beltran, Artur V. Cideciyan, Alfred S. Lewin, Simone Iwabe, Hemant Khanna, Alexander Sumaroka, Vince A. Chiodo, Diego S. Fajardo, Alejandro J. Román, Wen-Tao Deng, Malgorzata Swider, Tomas S. Alemán, Sanford L. Boye, Sem Genini, Anand Swaroop, William W. Hauswirth, Samuel G. Jacobson and Gustavo D. Aguirre is a continuation […]

    Feb 8, 2012 — Read more No Comments
  12. Notable Paper: Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

    Hereditary retinal dystrophies (retinitis pigmentosa, Leber congenital amaurosis, cone-rod dystrophies, macular degeneration) are characterized by loss of visual function, sometimes starting during early childhood, other times in late adulthood.  About 30% of these dystrophies are inherited in an autosomal dominant fashion (RetNet), caused by gain-of-function mutant alleles which encode a malignant form of a normal […]

    Nov 2, 2011 — Read more No Comments
  13. Proliferative reactive gliosis is compatible with glial metabolic support and neuronal function

    This paper by Vazquez-Chona FR, Swan A, Ferrell WD, Jiang L, Baehr W, Chien WM, Fero M, Marc RE and Levine EM addresses a long standing issue in the field of neuroscience: is the reactive phenotype of glial cells in and of itself detrimental to neural survival or function?

    Oct 17, 2011 — Read more No Comments
  14. Retinoid Receptors Trigger Neuritogenesis in Retinal Degenerations

    This paper by Y Lin, BW Jones, A Liu, JF Tucker, K Rapp, L Luo, W Baehr, PS Bernstein, CB Watt, JH Yang, MV Shaw and RE Marc examines the neuronal sprouting or neuritogenesis components of retinal remodeling found in retinal degenerative disease and describes a control process for retinoid X receptors (RXRs) in neuritogenesis. 

    Oct 11, 2011 — Read more 1 Comment
  15. Notable Paper: Virally Delivered Channelrhodopsin-2 Safely and Effectively Restores Visual Function in Multiple Mouse Models of Blindness

    This truly groundbreaking paper by M Mehdi Doroudchi, Kenneth P Greenberg, Jianwen Liu, Kimberly A Silka, Edward S Boyden, Jennifer A Lockridge, A Cyrus Arman, Ramesh Janani, Shannon E Boye, Sanford L Boye, Gabriel M Gordon, Benjamin C Matteo, Alapakkam P Sampath, William W Hauswirth and Alan Horsager demonstrates that channelrhodopsin-2, a cation channel from […]

    Jun 16, 2011 — Read more No Comments
  16. Alan Horsager speaks at TEDx

    I was talking with Dr. Alan Horsager the other day and was pleased to find out that he gave a brief talk at TEDx USC.  His talk was on a set of technologies and an approach that we in the Marclab are collaborating…

    Jun 6, 2011 — Read more No Comments
  17. Notable Paper: Tauroursodeoxycholic Acid (TUDCA) Prevents Retinal Degeneration in Transgenic P23H Rats

    May 23, 2011 — Read more No Comments
  18. Notable Papers: The Polymodal Ion Channel Transient Receptor Potential Vanilloid 4 Modulates Calcium Flux, Spiking Rate, and Apoptosis of Mouse Retinal Ganglion Cells

    May 19, 2011 — Read more 2 Comments
  19. Notable Papers: Otx2 Promotes the Survival of Damaged Adult Retinal Ganglion Cells and Protects against Excitotoxic Loss of Visual Acuity In Vivo

    Apr 17, 2011 — Read more No Comments