Maria Grant, Professor and Marilyn K. Glick Senior Chair, from the Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology and Department of Cellular and Integrative Physiology, Indiana University School of Medicine will be delivering a seminar in the Moran Eye Center auditorium on “A Broken Clock: Circadian Dysfunction In The Pathogenesis Of Diabetic Retinopathy” on Wednesday, October 1st at 11:00am.
Many disorders are characterized by circadian rhythm abnormalities, including disturbed sleep/wake cycles, changes in locomotor activity, and abnormal endocrine function. Animal models with mutations in circadian “clock genes” commonly show disturbances in reward processing, locomotor activity and novelty seeking behaviors. However, circadian clock dysfunction impacts diabetic complications including diabetic retinopathy. In this presentation, the impact of mutations in clock genes on retinal vascular function will be discussed. Circadian dysregulation of stem cells release from the bone marrow in diabetes will be described.