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  1. Missense variant in CST3 Exerts Recessive Effect On Susceptibility to AMD

    There is an interesting paper out demonstrating that CST3 exerts a recessive effect on susceptibility to AMD.  Cystatin C is a potent inhibitor of cysteine proteinases expressed by many tissues and in the eye, it is highly expressed by the retinal pigment epithelium (RPE). The team led by Luminita Paraoan recently reported data identifying a polymorphism in the […]

    Sep 22, 2015 — Read more No Comments