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  1. Age-Related Changes In The Daily Rhythm of Photoreceptor Functioning And Circuitry In A Melatonin-Proficient Mouse Strain

    This is an interesting study in PLoS One examining the involvement of melatonin in the retina, particularly in the survival of retinal neurons through aging studies in CH3-f+/+ mice, a melatonin proficient mouse strain.  As expected, certain physiological measures (a and b waves) are lost during aging, and in particular, the daily circadian rhythms of those measures. [...]

    Jun 5, 2012 — Read more No Comments

  2. Notable Paper: Localization of Melatonin Receptor 1 in Mouse Retina and Its Role in the Circadian Regulation of the Electroretinogram and Dopamine Levels

    I’ve watched the development of the circadian rhythm research starting with Joe Takahashi‘s work discovering CLOCK in the mammalian SCN back in 1994.  Since then there has been an explosion of circadian rhythm biology work including an I suppose, unsurprising amount of research in the retina proper. This paper by Anamika Sengupta, Kenkichi Baba, Francesca Mazzoni, Nikita V. Pozdeyev, Enrica [...]

    Oct 18, 2011 — Read more 1 Comment