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  1. Seminar: From Biomechanics to Proteomics – Toward the Mechanisms of Axonal Insult in Glaucoma

      Claude Burgoyne, Van Buskirk Chair for Ophthalmic Research and Director of the Optic Nerve Head Research Laboratory at the Devers Eye Institute in Portland, Oregon will be delivering a seminar on “From Biomechanics to Proteomics – Toward the Mechanisms of Axonal Insult in Glaucoma” on Wednesday, November 16th at 12:00 Noon in the Moran Eye Center auditorium. Dr. Burgoyne is […]

    Oct 27, 2016 — Read more No Comments
  2. TRPV4 Regulates Calcium Homeostasis, Cytoskeletal Remodeling, Conventional Outflow and Intraocular Pressure

    Glaucoma is the main cause of irreversible blindness in the world. In most common types of the disease, the optic nerve is damaged by an increase in intraocular pressure (IOP) which blocks fluid drainage through canals in the eye. There is currently no cure, however, the disease can be treated by lowering IOP. Unfortunately, all IOP-lowering drugs that in the market today target the […]

    Aug 17, 2016 — Read more No Comments
  3. Full-Length Axon Regeneration In The Adult Mouse Optic Nerve and Partial Recovery of Simple Visual Behaviors

    Friend of Webvision Yves Sauvé sent in this paper by Silmara de Lima, Yoshiki Koriyama, Takuji Kurimoto, Julia Teixeira Oliveira, Yuqin Yin, Yiqing Li, Hui-Ya Gilbert, Michela Fagiolini, Ana Maria Blanco Martinez, and Larry Benowitz that documents regeneration of the optic nerve in the adult mouse, a potentially substantial breakthrough in therapeutic recovery of vision lost through […]

    Jul 5, 2012 — Read more No Comments
  4. Missing optomotor head turning reflex in the DBA/2J mouse

    This paper by Peter Barabas, Wei Huang, Hui Chen, Christopher L. Koehler, Gareth Howell, Simon W.M. John, Ning Tian, René C Rentería and David Križaj is an outcome of an attempt to follow glaucoma progression in the DBA/2J mouse model of a naturally occurring, late onset form of glaucoma.  Ideally, a non-invasive technique should be used and in this case, […]

    Sep 13, 2011 — Read more No Comments
  5. Effect of General Anesthetics on IOP in Elevated IOP Mouse Model

    Elevated intraocular pressure (IOP) is the best recognized risk factor for the pathogenesis of glaucoma and the extent of retinal ganglion cell (RGC) degeneration in glaucoma is closely correlated with the extent of IOP elevation.  Therefore, accurately and reliably measuring IOP is critical in investigating the mechanism of pressure-induced RGC damage in glaucoma.  However, IOP […]

    Jul 2, 2011 — Read more No Comments
  6. Notable Papers: The Polymodal Ion Channel Transient Receptor Potential Vanilloid 4 Modulates Calcium Flux, Spiking Rate, and Apoptosis of Mouse Retinal Ganglion Cells

    May 19, 2011 — Read more 2 Comments
  7. Notable Papers: Otx2 Promotes the Survival of Damaged Adult Retinal Ganglion Cells and Protects against Excitotoxic Loss of Visual Acuity In Vivo

    Apr 17, 2011 — Read more No Comments