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  1. Bruch’s Membrane

    Bruch’s membrane is a highly specialized and multi-laminar structure in our retinas that forms the basis for mediating interactions between the retinal pigment epithelium and blood flow from the choroid.  I’ve not seen many good images online, so figured this image from mouse would be a good addition showing the relationship of the basal surface […]

    Sep 5, 2015 — Read more No Comments
  2. Seminar: Polarity, Signaling and Cross-talk In The Outer Retina

    Enrique Javier Rodriguez-Boulan, Charles and Margaret Dyson Professor Professor of Cell Biology, Neurosciences and Physiology at the Margaret Dyson Vision Research Institute, Department of Ophthalmology at Weill Cornell Medical College will be delivering a seminar on Polarity, Signaling and Cross-talk In The Outer Retina on Wednesday, April 8th at Noon in the the Moran Eye Center auditorium. Abstract: The polarized structure […]

    Mar 19, 2015 — Read more No Comments
  3. Thy-1 Expressed In CNV And Increased In migrating Choroidal ECs In Human Neovascular AMD

    This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by Haibo Wang, Yanchao Jiang and M. Elizabeth Hartnett. Thy-1 regulates VEGF-induced choroidal endothelial cell migration  Dept of Ophthalmology, John A. Moran Eye Center, The University of Utah-Salt Lake City.  Purpose: Choroidal endothelial cell (CEC) activation and migration […]

    May 8, 2014 — Read more No Comments
  4. Interesting Article: Mechanism of RPE Cell Death in α-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux

    I ran across an interesting paper in PLOS One published back in March of 2012 by Parameswaran G. Sreekumar, Christine Spee, Stephen J. Ryan, Susan P. C. Cole, Ram Kannan and David R. Hinton.  This manuscript looks at a mechanism of retinal pigment epithelium (RPE) cell death with notable findings identifying therapeutic targets for disorders that involve the RPE cells. The […]

    Feb 9, 2014 — Read more No Comments
  5. Activation of Rap1 Prevents Tumor Necrosis Factor Alpha-Induced ROS Generation in RPE

    This abstract was presented today at the Association for Research in Vision and Opthalmology (ARVO) meetings in Seattle, Washington by  Haibo Wang, Manabu McCloskey, Erika S. Wittchen and ME Hartnett.

    May 6, 2013 — Read more No Comments
  6. The Small GTPase Rap1 Regulates Intracellular ROS Generation in RPE

    Presented today at the Association for Research in Vision and Opthalmology (ARVO) meetings in Ft. Lauderdale, Florida by Haibo Wang, Erika S Wittchen, Dallas Shi, Dean Y Li and M. Elizabeth Hartnett.  Full size poster can be seen here.    

    May 9, 2012 — Read more No Comments
  7. Retinal Pigment Epithelium Cultures

    Friend of Webvision, Peter Westenskow in Marty Friedlander’s laboratory sent along this gorgeous image of retinal pigment epithelium (RPE) cells differentiating from induced pluripotent stem cells.  

    Nov 19, 2011 — Read more No Comments
  8. Rap1 GTPase is Involved in RPE Cell Barrier Function

    May 1, 2011 — Read more No Comments