Knockdown of Müller Cell Specific VEGF Reduces Retinal Neovascularization In A Rat Model of Retinopathy of Prematurity

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This abstract was presented today at the Association for Research in Vision and Opthalmology (ARVO) meetings in Seattle, Washington by Yanchao Jiang, Manabu McCloskey, Haibo Wang, Zhihong Yang, Jeremy Strange, Tal Kafir, John G Flannery, Kenneth Greenberg, Scott Hammond and ME Hartnett. Continue reading “Knockdown of Müller Cell Specific VEGF Reduces Retinal Neovascularization In A Rat Model of Retinopathy of Prematurity”

Seminar: The Role of VEGF in the Adult: Implications for Anti-VEGF Therapies

PowerPoint Presentation

Pat D’Amore, Senior Scientist and Director of Research at the Schepens Eye Research Institute/Massachusetts Eye and Ear.  Professor of  Ophthalmology and Pathology Harvard Medical School will be delivering a seminar at the John A. Moran Eye Center Auditorium on Tuesday, January 29, 2013 from 12:00-1:00 pm

Abstract:  VEGF has a well established role in vascular development and pathology; however, its possible function in the adult is just being investigated. Our observations point to critical roles for VEGF in various adult tissues, most notably the eye.  These findings have important implications for chronic VEGF blockage such as occurs with the long-term use of VEGF neutralizing therapies.

Astrocyte pVHL and HIF-α Isoforms Are Required for Embryonic-To-Adult Vascular Transition In The Eye

This paper from Toshihide Kurihara, Peter Westenskow, Tim Krohne, Edith Aguilar, Randy A. Johnson, and Marty Friedlander propose a model for the transition from embryonic to adult circulation in the eye  using a combinatorial gene deletion approach with over expression assays, examining astrocyte-targeted deletion of von Hippel-Lindau tumor suppressor (Vhl), hypoxia-inducible factor-αs (Hif-αs), and VEGF on normal regression of hyaloid vessels which are transient fetal vessels in the eye that can be seen in the second and early third trimester of human pregnancy.  Continue reading “Astrocyte pVHL and HIF-α Isoforms Are Required for Embryonic-To-Adult Vascular Transition In The Eye”