Retinal Fundus Images, Ground Truth of Vascular Bifurcations and Crossovers

The vasculature of the eye can provide amazing insight into systemic cardiovascular health.  For those studying the vasculature of the eye as an indicator of pathophysiological states, normative ground truth datasets become critically important.  Recently, George Azzopardi and Nicolai Petkov have made their annotated database of ground truth imagery of vascular bifurcations and crossovers in the retina available here.

 

Notable Paper: Localization of Melatonin Receptor 1 in Mouse Retina and Its Role in the Circadian Regulation of the Electroretinogram and Dopamine Levels

I’ve watched the development of the circadian rhythm research starting with Joe Takahashi‘s work discovering CLOCK in the mammalian SCN back in 1994.  Since then there has been an explosion of circadian rhythm biology work including an I suppose, unsurprising amount of research in the retina proper.

This paper by Anamika Sengupta, Kenkichi Baba, Francesca Mazzoni, Nikita V. Pozdeyev, Enrica StrettoiP. Michael Iuvone, and Gianluca Tosini describes the localization of type 1 melatonin receptors in the mouse retina that has interesting potential implications for additional circadian mechanisms in the retina.

Continue reading “Notable Paper: Localization of Melatonin Receptor 1 in Mouse Retina and Its Role in the Circadian Regulation of the Electroretinogram and Dopamine Levels”

Proliferative reactive gliosis is compatible with glial metabolic support and neuronal function

This paper by Vazquez-Chona FR, Swan A, Ferrell WD, Jiang L, Baehr W, Chien WM, Fero M, Marc RE and Levine EM addresses a long standing issue in the field of neuroscience: is the reactive phenotype of glial cells in and of itself detrimental to neural survival or function?

Continue reading “Proliferative reactive gliosis is compatible with glial metabolic support and neuronal function”

Retinoid Receptors Trigger Neuritogenesis in Retinal Degenerations

This paper by Y Lin, BW Jones, A Liu, JF Tucker, K Rapp, L Luo, W Baehr, PS Bernstein, CB Watt, JH Yang, MV Shaw and RE Marc examines the neuronal sprouting or neuritogenesis components of retinal remodeling found in retinal degenerative disease and describes a control process for retinoid X receptors (RXRs) in neuritogenesis.  Continue reading “Retinoid Receptors Trigger Neuritogenesis in Retinal Degenerations”

Nerve Fiber Layer (Nikon Small World Winner)

This years Nikon Small World Photomicrography Competition features some amazing work including this laser confocal image of a mouse nerve fiber layer on a retinal flatmount at 40X magnification by Gabriel Luna out of the Steve Fisher and Geoff Lewis’s retinal cell biology group at UC Santa Barbara Neuroscience Research Institute.

To see all of the images from this year’s competition, Boston.com’s The Big Picture has all of the stunning array of imagery.  Congratulations to Gabe on his efforts and look for more of their fantastic imagery here on Webvision in the near future.

Thanks to The Click for emailing us this link.