Functional and Anatomical Remodeling in Human Retinal Detachment

This manuscript by Clairton F de Souza, Michael Kalloniatis, Philip J Polkinghorne, Charles N J McGhee and Monica L Acosta examined retinal remodeling in response to a form of retinal detachment.  Rhegmatogenous retinal detachment.  The authors describe the changes observed and note that retinal plasticity is acute and likely occurs quickly enough that it may explain persistent vision loss post-reattachment.  They also later conclude that retinal detachment, particularly with macular involvement is an emergent condition which is a fundamentally important conclusion.

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Complicated Retinal Detatchment

This set of images (click the image above to enlarge) are optical coherence tomography (OCT) images of retained perfluoro-octane (PFO)  droplets after repair of a complicated retinal detachment.   PFO is a good surgical tool to help reattach the retina as they force sub retinal fluid out of any retinal tears and helps adhere the retina to the back of the globe.  PFO also helps localize the margins of retinal detachments, and reduces the height of the retinal detachment which assists in surgical laser photocoagulation.   Per Dr. Bernstein, “These subretinal droplets of PFO can remain in place indefinitely and cause minimal visual symptoms as long as they are not under or near the fovea.”

Images graciously provided to Webvision by Cyrie Fry of the Moran Eye Center.

Grand Teton Imaging In Ophthalmology Workshop

Imaging is such a crucial part of both clinical and basic research in ophthalmology and something that we have tried to show off here on Webvision in the Art of Vision category.  The Grand Teton Imaging in Ophthalmology Workshop is a meeting that is right in line with this imaging ethos and runs from September 12th to the 15th in one of the most beautiful places on planet Earth, Grand Teton National Park.

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Microglia Sculpt Postnatal Neural Circuits In An Activity And Complement-Dependent Manner

This very cool study by Dorothy P. Schafer, Emily K. Lehrman, Amanda G. Kautzman, Ryuta Koyama, Alan R. Mardinly, Ryo Yamasaki, Richard M. Ransohoff, Michael E. Greenberg, Ben A. Barres and Beth Stevens demonstrates how the immune system can participate in the circuitry of the developing mouse lateral genicular nucleus (LGN).

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Age-Related Changes In The Daily Rhythm of Photoreceptor Functioning And Circuitry In A Melatonin-Proficient Mouse Strain

This is an interesting study in PLoS One examining the involvement of melatonin in the retina, particularly in the survival of retinal neurons through aging studies in CH3-f+/+ mice, a melatonin proficient mouse strain.  As expected, certain physiological measures (a and b waves) are lost during aging, and in particular, the daily circadian rhythms of those measures.  However, the authors, Kenkichi Baba, Francesca Mazzoni, Sharon Owino, Susana Contreras-Alcantara, Enrica Strettoi and Gianluca Tosini did something really interesting and added exogenous melatonin to their assay and concluded that responsiveness of exogenous melatonin is also reduced during aging.