Notable Paper: Paired-Pulse Plasticity In The Strength and Latency of Light-Evoked Lateral Inhibition to Retinal Bipolar Cell Terminals

Paired Pulse plasticity

I’ve been doing some reading in plasticity recently and found this paper in the Journal of Neuroscience by Evan Vickers, Mean-Hwan Kim, Jozsef Vigh, and Henrique von Gersdorff published last summer that looks at short term plasticity in the Inner Plexiform Layer mediating light adaptation.  Working in goldfish (Carassius auratus auratus) retina (an amazing retina), Vickers et. al. used patch clamp recordings on Mb bipolar cell terminals with paired-pulse light stimulation.  The idea was to examine and quantify plasticity in GABAergic lateral IPSCs with findings that show variation in the synaptic strength and latencies which correspond to adaptation and sensitization to surround temporal contrast.  The authors found that there are separate retinal circuitry pathways, each with differing mechanisms of plasticity that help to tune temporal response curves with glutamate release from ON bipolar cell terminals.  They conclude that “Short-term plasticity of L-IPSCs may thus influence the strength, timing, and spatial extent of amacrine and ganglion cell inhibitory surrounds”.

 

100 Papers You Should Read: Visual Pigments of Single Goldfish Cones

This is the fourth paper in the category, 100 Papers You Should Read (in vision science).

William Rushton once said “The trouble with colour vision is the mentality of those that write on it-and of those that read.  In most aspects of physiology it is sufficient to offer a fairly plausible and adequate hypothesis; but colour visionaries want nothing less than the truth.  The cause of this unreasonable demand lies in this, that whereas nearly all the phenomena of nature are simply observed, those of sensory physiology can also be experienced.  So in colour vision we perceive the essential hollowness of formal scientific explanation.”

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