Light-Evoked Synaptic Activity of Retinal Ganglion and Amacrine Cells is Regulated in Developing Mouse Retina

This paper by Q. He, Wang P and Ning Tian characterizes the developmental profiles of the light evoked excitatory and inhibitory synaptic inputs from ON and OFF synaptic pathways in the retina, the light evoked synaptic outputs and the sensitivity of the light evoked synaptic inputs and outputs to light deprivation of retinal ganglion cells (RGCs) and displaced amacrine cells (ACs) of developing mouse retina.  The results strongly suggest that spontaneous and light-evoked synaptic activities of RGCs and ACs are regulated by different synaptic mechanisms.

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A Photographers Visit to the Moran Eye Center

A friend of Webvision, renaissance man and photographer extraordinaire, Duncan Davidson visited us at the Moran Eye Center and hung out for a day of science while we performed experiments.  Duncan documented some of the work we did that day in the lovely video he posted to Vimeo above.  You have quite possibly seen Duncan’s work before on CNN or of individuals giving talks at the TED conference as Duncan is the official TED photographer.

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Stargardt’s Disease angiogram

Venous phase fluorescein sodium angiogram of a dark choroid in Stargardt’s disease or fundus flavimaculatus.  Stargart’s Disease is a progressive retinal degenerative disease caused by mutations in one of 3 genes, ABCA4, ELOVL4 or PROM1.  The disease is a form of juvenile onset macular degeneration affecting the retinal pigmented epithelium (RPE).  The disease onset and progression is usually bilateral.

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