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  1. TRPV4 Regulates Calcium Homeostasis, Cytoskeletal Remodeling, Conventional Outflow and Intraocular Pressure

    Glaucoma is the main cause of irreversible blindness in the world. In most common types of the disease, the optic nerve is damaged by an increase in intraocular pressure (IOP) which blocks fluid drainage through canals in the eye. There is currently no cure, however, the disease can be treated by lowering IOP. Unfortunately, all IOP-lowering drugs that in the market today target the […]

    Aug 17, 2016 — Read more No Comments
  2. New Webvision Chapter: Retinal Degeneration, Remodeling and Plasticity

    We have a new Webvision chapter on Retinal Degeneration, Remodeling and Plasticity! Check it out here.

    Jun 1, 2015 — Read more No Comments
  3. Progression of Geographic Atrophy

    These retinal images are from an 84 year old white male who presented to the Moran Eye Center in 2008.  He was diagnosed and followed for dry age-related macular degeneration (AMD) with serial autofluorescent photographs showing progression of geographic atrophy of the RPE from 2008 to 2014. These images were prepared by James Gilman of the Moran Eye Center.   […]

    May 28, 2015 — Read more No Comments
  4. Müller Cell Metabolic Chaos During Degeneration

    This abstract was presented today at the 2015 Association for Research in Vision and Opthalmology (ARVO) meetings in Denver, Colorado by  Rebecca L. Pfeiffer, Bryan W. Jones and Robert E. Marc. Purpose: Müller cells (MCs) play a critical role in glutamate (E) metabolism and carbon skeleton cycling in retina. MCs demonstrate changes in metabolism and morphology during retinal degeneration. The timing, […]

    May 7, 2015 — Read more No Comments
  5. Seminar: Cellular Response Associated to Retinal Diseases and Therapeutic Approaches

    Nicolás Cuenca, professor Department of Physiology,Genetics and Microbiology University of Alicante Spain will be delivering a seminar, Cellular Response Associated to Retinal Diseases and Therapeutic Approaches on Monday, May 11thth at Noon in the the Moran Eye Center auditorium.   Abstract: At the cellular and molecular level, the response to retinal injury is similar in diseases like AMD, glaucoma, diabetic retinopathy and retinitis pigmentosa. […]

    Apr 23, 2015 — Read more No Comments
  6. Upcoming VIG: March 19th @ NOON

    There is an upcoming Vision Interest Group featuring Stephan Baehr from the DeAngelis Lab and Jacki Roberts from the Fu Lab.  Will be held on March 19th at noon in the west John A. Moran Eye Center Auditorium.

    Mar 11, 2015 — Read more No Comments
  7. Lasker/IRRF Report On Restoring Vision

    I participated in the Lasker/IRRF Initiative on Restoring Vision to the Blind in March 2014. It was a great session of research leaders working on various approaches to restore visual function lost by retinal degenerative disease. The purpose of the meeting was to identify the key issues hampering research progress and to develop innovative proposals […]

    Feb 27, 2015 — Read more No Comments
  8. Upcoming VIG: February 19th @NOON Moran Auditorium west

    There is an upcoming Vision Interest Group featuring Felix Vazquez-Chona from the Marc and Levine Labs and Brent Young from the Tian Lab.  Will be held on February 19th at noon in the west John A. Moran Eye Center Auditorium.

    Feb 10, 2015 — Read more No Comments
  9. Seminar: How Inhibiting The Dimerization Of Vitamin A and/or Catalyzing The Reduction of Quinones May Prevent Retinal Degeneration

    Ilyas Washington from Columbia University Medical Center will be delivering a seminar on How Inhibiting The Dimerization Of Vitamin A and/or Catalyzing The Reduction of Quinones May Prevent Retinal Degeneration on Wednesday, February 11th, 2015 in the Moran Eye Center auditorium. Abstract:  Many human conditions, originating from multiple genetic and environmental pressures, converge to overproduce superoxide radical anions. The […]

    Feb 2, 2015 — Read more No Comments
  10. Upcoming VIG seminar: November 20th @ NOON

    There is an upcoming Vision Interest Group featuring Kevin Breen from the Vetter lab and Crystal Sigulinsky from the Marc Lab.  Will be held on November 20th at noon in the west John A. Moran Eye Center Auditorium.

    Nov 10, 2014 — Read more No Comments
  11. Seminar: Light Damage

    Jeannie Chen, Professor in the Department of Cell and Neurobiology, the Zikha Neurogenetic Institute, Keck School of Medicine, University of Southern California will present a seminar at noon on Wednesday, September 17th in the Moran Eye Center auditorium on Light Damage. Abstract:  Excessive light exposure is known to harm the retina and exacerbates disease progression […]

    Sep 2, 2014 — Read more No Comments
  12. What It’s Like To Go Blind

    This is important for scientists and non-scientists alike.  You might be surprised at how many people do not know someone who is blind or has gone through a blinding disease.  You might be further surprised at how many scientists that are engaged in vision research do not really know what its like to have gone through […]

    Aug 28, 2014 — Read more No Comments
  13. The Judgment Of Solomon

    I had the honor and privilege of attending a Lasker/IRRF Initiative’s plenary session on Restoring Vision to the Blind at Janelia Farm last month where Mr. Sanford D. Greenberg delivered an emotional and inspiring story of a time in his life where he lost his vision during his junior year at Columbia University.  The prospect of […]

    May 15, 2014 — Read more 2 Comments
  14. Metabolic Changes Associated With Müller Cells In A Transgenic Rabbit Model Of Retinal Degeneration

    This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by  Rebecca L. Pfeiffer, Bryan W. Jones and Robert E. Marc. Purpose: Müller cells play a central role in retinal metabolism via the glutamate cycle. During retinal degeneration Müller cells are among the first to demonstrate changes, reflected […]

    May 4, 2014 — Read more No Comments
  15. Retinitis Pigmentosa 2 Protein Regulates Transport Of Isoprenylated Proteins To Photoreceptor Outer Segments

    This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by Houbin Zhang, Li Jiang, Christin Hanke and Wolfgang Baehr. Full size poster can be downloaded here. Purpose: X-linked retinitis pigmentosa (XLRP) is a devastating form of retinal degeneration, manifesting early in life with symptoms of night blindness, visual […]

    May 4, 2014 — Read more No Comments
  16. Arl3 Rod-Specific Knockout Displays RP-Like Photoreceptor Degeneration

    This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by Christin Hanke, Houbin Zhang, Cecilia D. Gerstner, Jeanne M. Frederick AND Wolfgang Baehr. Full size poster can be downloaded here. Purpose: Arf-like protein 3 (Arl3) localizes predominantly in the photoreceptor inner segment. Germline Arl3 knockout mice do not […]

    May 4, 2014 — Read more No Comments
  17. Notes On Blindness

    “In 1983, after years of deteriorating vision, John Hull went completely blind. For the next three years he kept a diary on audiocassette. This film is a dramatization using his original recordings.”

    Mar 19, 2014 — Read more No Comments
  18. Interesting Article: Mechanism of RPE Cell Death in α-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux

    I ran across an interesting paper in PLOS One published back in March of 2012 by Parameswaran G. Sreekumar, Christine Spee, Stephen J. Ryan, Susan P. C. Cole, Ram Kannan and David R. Hinton.  This manuscript looks at a mechanism of retinal pigment epithelium (RPE) cell death with notable findings identifying therapeutic targets for disorders that involve the RPE cells. The […]

    Feb 9, 2014 — Read more No Comments
  19. Interesting: Gene Regulator, Onecut1 Important To Retinal Development And Integrity

    This paper, Onecut1 Is Essential for Horizontal Cell Genesis and Retinal Integrity in the Journal of Neuroscience by authors Fuguo Wu, Renzhong Li, Yumiko Umino, Tadeusz J. Kaczynski, Darshan Sapkota, Shengguo Li, Mengqing Xiang, Steven J. Fliesler, David M. Sherry, Maureen Gannon, Eduardo Solessio, and Xiuqian Mu describes the gene regulator Onecut1 as being the key to healthy retinal […]

    Oct 2, 2013 — Read more No Comments
  20. The Cilium

    With the exception of a few types of cells, (acinar cells, T lymphocytes and hepatocytes), every cell in your body has a cilia.  In the vision community, we are used to seeing these structures in the distal portion of the photoreceptors.  The reality is that every cell in the retina has a cilium and some cells […]

    Jun 7, 2013 — Read more No Comments
  21. Retinal Remodeling in a Rat Model of the Smith-Lemli-Opitz Syndrome (SLOS)

    This abstract was presented today at the Association for Research in Vision and Opthalmology (ARVO) meetings in Seattle, Washington by Steven J. Fliesler, Christopher C. Goulah, W. Drew Ferrell, Robert E. Marc and Bryan W. Jones.

    May 5, 2013 — Read more No Comments
  22. Interesting paper: Characterization Of Neurite Outgrowth And Ectopic Synaptogenesis In Response To Photoreceptor Dysfunction

    Authors Stylianos Michalakis, Karin Schäferhoff, Isabella Spiwoks-Becker, Nawal Zabouri, Susanne Koch, Fred Koch, Michael Bonin, Martin Biel, and Silke Haverkamp have a new paper out that looks at the earliest gene microarray analysis results associated with neurite outgrowth in the degenerate retina.  The title is a overly broad, but the results focusing on gene expression changes […]

    Apr 26, 2013 — Read more No Comments
  23. Activation of Survival Pathways In The Degenerating Retina of rd10 Mice

    An interesting article was published  in Experimental Eye Research by Marijana Samardzija, Hedwig Wariwoda, Cornelia Imsand, Philipp Huber, Severin R. Heynen, Andrea Gubler and Christian Grimm that examines survival pathways that are induced in the retinas of rd10 mice.  Dynamics of retinal degeneration in the rd10 mouse was also examined including an analysis of retinal vasculature and […]

    Jan 25, 2013 — Read more No Comments
  24. Seminar: Mechanisms Of Retinal Degeneration Caused By Mutant Rhodopsin: Applications Of Live Rod Imaging

    Barry Knox from Upstate University of New York, Departments of Neuroscience and Physiology, Biochemistry and Molecular Biology and Ophthalmology will be  delivering a talk on Mechanisms Of Retinal Degeneration Caused By Mutant Rhodopsin: Applications Of Live Rod Imaging, January 22nd, 2013 in the John A. Moran Eye Center Auditorium.

    Jan 15, 2013 — Read more No Comments
  25. Interesting Paper: Gene Expression Changes Within Müller Glial Cells in Retinitis Pigmentosa

    Retinal degenerations are accompanied by retinal remodeling events.  These events alter the structure and function of the retina and involve to a large extent, Müller cells which seem to serve as pathways for neuronal migration.  This paper by Karin Roesch, Michael B. Stadler and Constance L. Cepko looks at gene expression changes in the Müller cells, one […]

    Nov 13, 2012 — Read more No Comments