Seminar: Retinal Pigment Epithelial Cell Bystander Effects Contribute to AMD Pathology

Barbel Rohrer, the SmartState Endowed Chair in Gene and Pharmacological Treatment Of Retinal Degenerative Diseases at Medical University South Carolina will be delivering a seminar on “Retinal Pigment Epithelial Cell Bystander Effects Contribute to AMD pathology” on Wednesday, April 18th at 12:00 Noon in the  Moran Eye Center auditorium.

Abstract: Retinal pigment epithelium damage in age-related macular degeneration is triggered in many different locations, suggesting that damage occurs in susceptible areas, while delaying damage in more resilient areas. I will be describing experiments to distinguish two different mechanisms that would mediate the bystander effect: transfer of a signal to the recipient cells by exosomes; or the spread of information by means of communication via gap junctions.

Dr. Gregory Hageman Delivers Congressional Briefing

The Moran Eye Center‘s Dr. Gregory Hageman delivered a Congressional Briefing on September 20th along with the Alliance for Eye and Vision Research (AEVR) and partners AMD Alliance International, Alliance for Aging Research, Association for Research in Vision and Ophthalmology (ARVO), European Vision Institute and Lighthouse International.  Dr. Hageman spoke as part of a Congressional briefing as part of International Age-related Macular Degeneration (AMD) Awareness Week 2012.

Dr. Gregory Hageman, Executive Director of the Center for Translational Medicine (CTM) at the John A. Moran Eye Center at the University of Utah related in his address that AMD consists of multiple biological diseases.  Dr. Hageman continued by expressing that a convergence of clinical, biological and genetic data has led to a stronger understanding of the disease and new hope for the development of diagnostics and therapeutic interventions currently underway.

More details of the briefing are available on the NAEVR website here.

Macular pigment imaging in AREDS2 participants: An ancillary study of AREDS2 subjects enrolled at the Moran Eye Center

 

This study by Paul S. Bernstein, Faisal Ahmed, Aihua Liu, Susan Allman, Xiaoming Sheng, Mohsen Sharifzadeh, Igor Ermakov, and Werner Gellermann in IOVS examined the macular pigment in AREDS2 patients.  AREDS2 is a randomized, placebo-controlled study designed to determine whether supplementation with 10 mg of lutein and 2 mg of zeaxanthin per day can slow the rate of progression of age-related macular degeneration (AMD). Continue reading “Macular pigment imaging in AREDS2 participants: An ancillary study of AREDS2 subjects enrolled at the Moran Eye Center”

Notable Paper: Increased Expression of Multifunctional Serine Protease, HTRA1, in Retinal Pigment Epithelium Induces Polypoidal Choroidal Vasculopathy

Efforts to explore chromosome 10q26, a major candidate region associated with age-related macular degeneration (AMD) have proven difficult and controversial.  This particular region of interest is two neighboring genes, ARMS2 and HTRA1.  However, efforts in trying to explore the functional involvement of either HTRA1 or ARMS2 in AMD have proven to be difficult and have often yielded conflicting results.

Continue reading “Notable Paper: Increased Expression of Multifunctional Serine Protease, HTRA1, in Retinal Pigment Epithelium Induces Polypoidal Choroidal Vasculopathy”