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  1. Notable Paper: Ras Pathway Inhibition Prevents Neovascularization By Repressing Endothelial Cell Sprouting

    A new manuscript in the Journal of Clinical Investigation (on the cover) by Peter D. Westenskow, Toshihide Kurihara, Edith Aguilar, Elizabeth L. Scheppke, Stacey K. Moreno, Carli Wittgrove, Valentina Marchetti, Iacovos P. Michael, Sudarshan Anand, Andras Nagy, David Cheresh and Martin Friedlander at The Scripps Research Institute describes a new technique for treating aberrant growth of blood vessels in […]

    Nov 20, 2013 — Read more No Comments
  2. Astrocyte pVHL and HIF-α Isoforms Are Required for Embryonic-To-Adult Vascular Transition In The Eye

    This paper from Toshihide Kurihara, Peter Westenskow, Tim Krohne, Edith Aguilar, Randy A. Johnson, and Marty Friedlander propose a model for the transition from embryonic to adult circulation in the eye  using a combinatorial gene deletion approach with over expression assays, examining astrocyte-targeted deletion of von Hippel-Lindau tumor suppressor (Vhl), hypoxia-inducible factor-αs (Hif-αs), and VEGF […]

    Jan 13, 2012 — Read more No Comments