Interesting paper: Characterization Of Neurite Outgrowth And Ectopic Synaptogenesis In Response To Photoreceptor Dysfunction

Gene heat map

Authors Stylianos Michalakis, Karin Schäferhoff, Isabella Spiwoks-Becker, Nawal Zabouri, Susanne Koch, Fred Koch, Michael Bonin, Martin Biel, and Silke Haverkamp have a new paper out that looks at the earliest gene microarray analysis results associated with neurite outgrowth in the degenerate retina.  The title is a overly broad, but the results focusing on gene expression changes in the A3B1 mouse retina (a CNGA3/CNGB1 double-knockout) are intriguing, particularly their proposal that Tp53, Smad and Stat3 signaling contribute to synaptic plasticity at least. Continue reading “Interesting paper: Characterization Of Neurite Outgrowth And Ectopic Synaptogenesis In Response To Photoreceptor Dysfunction”