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  1. New Webvision Chapter: Retinal Degeneration, Remodeling and Plasticity

    We have a new Webvision chapter on Retinal Degeneration, Remodeling and Plasticity! Check it out here.

    Jun 1, 2015 — Read more No Comments
  2. Müller Cell Metabolic Chaos During Degeneration

    This abstract was presented today at the 2015 Association for Research in Vision and Opthalmology (ARVO) meetings in Denver, Colorado by  Rebecca L. Pfeiffer, Bryan W. Jones and Robert E. Marc. Purpose: Müller cells (MCs) play a critical role in glutamate (E) metabolism and carbon skeleton cycling in retina. MCs demonstrate changes in metabolism and morphology during retinal degeneration. The timing, […]

    May 7, 2015 — Read more No Comments
  3. Seminar: Cellular Response Associated to Retinal Diseases and Therapeutic Approaches

    Nicolás Cuenca, professor Department of Physiology,Genetics and Microbiology University of Alicante Spain will be delivering a seminar, Cellular Response Associated to Retinal Diseases and Therapeutic Approaches on Monday, May 11thth at Noon in the the Moran Eye Center auditorium.   Abstract: At the cellular and molecular level, the response to retinal injury is similar in diseases like AMD, glaucoma, diabetic retinopathy and retinitis pigmentosa. […]

    Apr 23, 2015 — Read more No Comments
  4. Seminar: How Inhibiting The Dimerization Of Vitamin A and/or Catalyzing The Reduction of Quinones May Prevent Retinal Degeneration

    Ilyas Washington from Columbia University Medical Center will be delivering a seminar on How Inhibiting The Dimerization Of Vitamin A and/or Catalyzing The Reduction of Quinones May Prevent Retinal Degeneration on Wednesday, February 11th, 2015 in the Moran Eye Center auditorium. Abstract:  Many human conditions, originating from multiple genetic and environmental pressures, converge to overproduce superoxide radical anions. The […]

    Feb 2, 2015 — Read more No Comments
  5. Upcoming VIG: September 18th @ NOON

    There is an upcoming Vision Interest Group featuring Hui Xu from the Yingbin Fu lab and Rebecca Pfeiffer from the Marc Lab.  Will be held on September 18th at noon in the west John A. Moran Eye Center Auditorium.

    Sep 10, 2014 — Read more No Comments
  6. Metabolic Changes Associated With Müller Cells In A Transgenic Rabbit Model Of Retinal Degeneration

    This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by  Rebecca L. Pfeiffer, Bryan W. Jones and Robert E. Marc. Purpose: Müller cells play a central role in retinal metabolism via the glutamate cycle. During retinal degeneration Müller cells are among the first to demonstrate changes, reflected […]

    May 4, 2014 — Read more No Comments
  7. Seminar: Mechanisms Of Retinal Degeneration Caused By Mutant Rhodopsin: Applications Of Live Rod Imaging

    Barry Knox from Upstate University of New York, Departments of Neuroscience and Physiology, Biochemistry and Molecular Biology and Ophthalmology will be  delivering a talk on Mechanisms Of Retinal Degeneration Caused By Mutant Rhodopsin: Applications Of Live Rod Imaging, January 22nd, 2013 in the John A. Moran Eye Center Auditorium.

    Jan 15, 2013 — Read more No Comments
  8. Seminar: Genetics of Inherited Retinal Degenerations: Genetic Diagnostic Testing and Novel Disease Gene Discovery

      Eric Pierce from the Massachusetts Eye and Ear Infirmary and Harvard Medical School Department of Ophthalmology will be delivering a talk on Genetics of Inherited Retinal Degenerations: Genetic Diagnostic Testing and Novel Disease Gene Discovery Monday, December 10th at 12:00pm in the John A. Moran Eye Center Auditorium. Abstract: Inherited retinal degenerations (IRDs) are important causes […]

    Dec 4, 2012 — Read more No Comments
  9. Interesting Paper: Gene Expression Changes Within Müller Glial Cells in Retinitis Pigmentosa

    Retinal degenerations are accompanied by retinal remodeling events.  These events alter the structure and function of the retina and involve to a large extent, Müller cells which seem to serve as pathways for neuronal migration.  This paper by Karin Roesch, Michael B. Stadler and Constance L. Cepko looks at gene expression changes in the Müller cells, one […]

    Nov 13, 2012 — Read more No Comments
  10. Notable Paper: Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

    How photoreceptor cells go through the process of cell death has been an outstanding question.  The authors of this paper by Yusuke Murakami, Hidetaka Matsumoto, Miin Roh, Jun Suzuki, Toshio Hisatomi, Yasuhiro Ikeda, Joan W. Miller, and Demetrios G. Vavvas have further defined the process and identified the receptor interacting protein kinase (RIP) pathway as a […]

    Aug 28, 2012 — Read more No Comments
  11. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells

    This is an important issue for anyone involved in using murine models of retinal degeneration.  It turns out that contamination of Rd8 mutation in the B6 mice is more wide spread than the C57BL/6N mice.  Labs worldwide are going to have to reassess their data due to this mutation and all reviewers will ask about this […]

    Aug 9, 2012 — Read more No Comments
  12. Undersized Dendritic Arborizations in Retinal Ganglion Cells of the rd1 Mutant Mouse: A Paradigm of Early Onset Photoreceptor Degeneration

    This paper by Devid Damiani, Elena Novelli, Francesca Mazzoni and Enrica Strettoi documents continued negative plasticity in retina by examining ganglion cells in the rd1 mouse.  The rd1 mouse is one of many models of retinal degenerative disease, in this case as an autosomal recessive retinal degenerative disease.  This work gets at the remodeling issue […]

    Aug 8, 2012 — Read more No Comments
  13. Review: Defective Trafficking of Rhodopsin and Its Role In Retinal Degenerations

    This is a great review paper on the role of rhodopsin trafficking and its influence on retinal degenerative disease by TJ Hollingsworth and Alecia Gross.  Rhodopsin delocalization in rod photoreceptors has been recognized for some time as one of the first indications of retinal photoreceptor cell stress in retinal degenerative diseases, so I was intrigued […]

    Mar 15, 2012 — Read more No Comments
  14. Dysmorphic Photoreceptors in a P23H Mutant Rhodopsin Model of Retinitis Pigmentosa Are Metabolically Active and Capable of Regenerating to Reverse Retinal Degeneration

    This paper (and the cover article) is the result of a collaborative effort between Damian C. Lee, Felix R. Vazquez-Chona, W. Drew Ferrell, Beatrice M. Tam, Bryan W. Jones, Robert E. Marc, and Orson L. Moritz.

    Feb 29, 2012 — Read more No Comments
  15. Notable Paper: Gene Therapy Rescues Photoreceptor Blindness in Dogs and Paves The Way for Treating Human X-linked Retinitis Pigmentosa

    This paper in PNAS by William A. Beltran, Artur V. Cideciyan, Alfred S. Lewin, Simone Iwabe, Hemant Khanna, Alexander Sumaroka, Vince A. Chiodo, Diego S. Fajardo, Alejandro J. Román, Wen-Tao Deng, Malgorzata Swider, Tomas S. Alemán, Sanford L. Boye, Sem Genini, Anand Swaroop, William W. Hauswirth, Samuel G. Jacobson and Gustavo D. Aguirre is a continuation […]

    Feb 8, 2012 — Read more No Comments
  16. Metabolic Profiling of Activated Retinal Glia

    Presented at the Society for Neuroscience meetings in Washington, D.C. by Felix Vazquez-Chona, William Drew Ferrell, Ed Levine, Bryan William Jones and Robert E. Marc.  Full size poster can be seen here.

    Nov 18, 2011 — Read more No Comments
  17. Retinoid Receptors Trigger Neuritogenesis in Retinal Degenerations

    This paper by Y Lin, BW Jones, A Liu, JF Tucker, K Rapp, L Luo, W Baehr, PS Bernstein, CB Watt, JH Yang, MV Shaw and RE Marc examines the neuronal sprouting or neuritogenesis components of retinal remodeling found in retinal degenerative disease and describes a control process for retinoid X receptors (RXRs) in neuritogenesis. 

    Oct 11, 2011 — Read more 1 Comment
  18. Notable Paper: Retinal Remodeling in the Tg P347L Rabbit, a Large-Eye Model of Retinal Degeneration

    This paper is the result of a collaborative effort between Bryan William Jones, Mineo Kondo and Hiroko Terasaki, Carl Watt, Kevin Rapp, James Anderson, Yanhua Lin, Maggie Shaw, Jia-Hui Yang and Robert Marc. This work presents a substantial advance in models of Retinitis pigmentosa (RP), an set of inherited blinding diseases characterized by progressive loss of retinal photoreceptors.  

    Aug 4, 2011 — Read more 1 Comment
  19. Cone Opsin Determines The Time Course of Cone Photoreceptor Degeneration in Leber Congenital Amaurosis

    It is been long known that ventral and central cones degenerate more rapidly than dorsal cones in retinoid-deprived LCA (Leber’s Congenital Amaurosis) models.  This paper in PNAS by Tao Zhang, Wolfgang Baehr…

    Jun 13, 2011 — Read more No Comments
  20. Notable Paper: Tauroursodeoxycholic Acid (TUDCA) Prevents Retinal Degeneration in Transgenic P23H Rats

    May 23, 2011 — Read more No Comments
  21. Visual Restoration And Circuitry-Retinal Sheet Transplants To Rats With Retinal Degeneration

    May 4, 2011 — Read more No Comments
  22. Genetic Dissection of p27-Mediated Reactive Gliosis

    May 3, 2011 — Read more No Comments
  23. CaMKII Signaling is Contributive to Neuritogenesis in Light-Induced Retinal Degeneration

    May 2, 2011 — Read more No Comments