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  1. Müller Cell Metabolic Chaos During Degeneration

    This abstract was presented today at the 2015 Association for Research in Vision and Opthalmology (ARVO) meetings in Denver, Colorado by  Rebecca L. Pfeiffer, Bryan W. Jones and Robert E. Marc. Purpose: Müller cells (MCs) play a critical role in glutamate (E) metabolism and carbon skeleton cycling in retina. MCs demonstrate changes in metabolism and morphology during retinal degeneration. The timing, […]

    May 7, 2015 — Read more No Comments
  2. Retinitis Pigmentosa 2 Protein Regulates Transport Of Isoprenylated Proteins To Photoreceptor Outer Segments

    This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by Houbin Zhang, Li Jiang, Christin Hanke and Wolfgang Baehr. Full size poster can be downloaded here. Purpose: X-linked retinitis pigmentosa (XLRP) is a devastating form of retinal degeneration, manifesting early in life with symptoms of night blindness, visual […]

    May 4, 2014 — Read more No Comments
  3. Glass Like Retinitis Pigmentosa

    In yet another example of art imitating life.  At the last ARVO meeting, a couple of us went up to the Chihuly garden in Seattle and ran across a piece of blown glass which stunningly, reminded me of what the human retina looks like in a patient suffering from the blinding disease, retinitis pigmentosa. More over on Jonesblog.  

    Jan 7, 2014 — Read more No Comments
  4. Notable Paper: Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

    How photoreceptor cells go through the process of cell death has been an outstanding question.  The authors of this paper by Yusuke Murakami, Hidetaka Matsumoto, Miin Roh, Jun Suzuki, Toshio Hisatomi, Yasuhiro Ikeda, Joan W. Miller, and Demetrios G. Vavvas have further defined the process and identified the receptor interacting protein kinase (RIP) pathway as a […]

    Aug 28, 2012 — Read more No Comments
  5. Undersized Dendritic Arborizations in Retinal Ganglion Cells of the rd1 Mutant Mouse: A Paradigm of Early Onset Photoreceptor Degeneration

    This paper by Devid Damiani, Elena Novelli, Francesca Mazzoni and Enrica Strettoi documents continued negative plasticity in retina by examining ganglion cells in the rd1 mouse.  The rd1 mouse is one of many models of retinal degenerative disease, in this case as an autosomal recessive retinal degenerative disease.  This work gets at the remodeling issue […]

    Aug 8, 2012 — Read more No Comments
  6. Histologic Correlation of OCT With Diseased Retina In Humans

    This poster was presented today at the Association for Research in Vision and Opthalmology (ARVO) meetings in Ft. Lauderdale, Florida by W. Drew Ferrell, Lloyd Williams, Carl B. Watt, James R. Anderson, Robert E. Marc and Bryan William Jones.  Full size (almost) poster can be seen here.

    May 6, 2012 — Read more No Comments
  7. Rapid Glutamate Receptor 2 Trafficking During Retinal Degeneration

    Yanhua Lin, Bryan W. Jones, Aihua Liu, Félix R. Vazquéz-Chona, J. Scott Lauritzen, W. Drew Ferrell and Robert E. Marc published a paper on rapid changes in glutamate receptor 2 trafficking during retinal degeneration.

    May 1, 2012 — Read more No Comments
  8. Notable Paper: Gene Therapy Rescues Photoreceptor Blindness in Dogs and Paves The Way for Treating Human X-linked Retinitis Pigmentosa

    This paper in PNAS by William A. Beltran, Artur V. Cideciyan, Alfred S. Lewin, Simone Iwabe, Hemant Khanna, Alexander Sumaroka, Vince A. Chiodo, Diego S. Fajardo, Alejandro J. Román, Wen-Tao Deng, Malgorzata Swider, Tomas S. Alemán, Sanford L. Boye, Sem Genini, Anand Swaroop, William W. Hauswirth, Samuel G. Jacobson and Gustavo D. Aguirre is a continuation […]

    Feb 8, 2012 — Read more No Comments
  9. Generation of An Inbred Miniature Pig Model of Retinitis Pigmentosa

    A recent paper by Jason W. Ross, Juan P. Fernandez de Castro, Jianguo Zhao, Melissa Samuel, Eric Walters, Cecilia Rios, Patricia Bray-Ward, Bryan W. Jones, Robert E. Marc, Wei Wang, Liang Zhou, Jennifer M. Noel, Maureen A. McCall, Paul J. DeMarco, Randall S. Prather and Henry J. Kaplan describes the creation of a new model of retinal degenerative disease, specifically autosomal dominant retinitis pigmentosa in a miniature pig model, […]

    Feb 7, 2012 — Read more No Comments
  10. RD 2012: XVth International Symposium on Retinal Degeneration Announcement

    We just received program notice of the XVth International Symposium on Retinal Degeneration that will be held, July 16-20, 2012 Bad Gögging, Bavaria, Germany.

    Dec 12, 2011 — Read more No Comments
  11. Notable Paper: Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

    Hereditary retinal dystrophies (retinitis pigmentosa, Leber congenital amaurosis, cone-rod dystrophies, macular degeneration) are characterized by loss of visual function, sometimes starting during early childhood, other times in late adulthood.  About 30% of these dystrophies are inherited in an autosomal dominant fashion (RetNet), caused by gain-of-function mutant alleles which encode a malignant form of a normal […]

    Nov 2, 2011 — Read more No Comments
  12. Notable Paper: Retinal Remodeling in the Tg P347L Rabbit, a Large-Eye Model of Retinal Degeneration

    This paper is the result of a collaborative effort between Bryan William Jones, Mineo Kondo and Hiroko Terasaki, Carl Watt, Kevin Rapp, James Anderson, Yanhua Lin, Maggie Shaw, Jia-Hui Yang and Robert Marc. This work presents a substantial advance in models of Retinitis pigmentosa (RP), an set of inherited blinding diseases characterized by progressive loss of retinal photoreceptors.  

    Aug 4, 2011 — Read more 1 Comment
  13. Notable Paper: Tauroursodeoxycholic Acid (TUDCA) Prevents Retinal Degeneration in Transgenic P23H Rats

    May 23, 2011 — Read more No Comments