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  1. Suppressing Thyroid Hormone Signaling Preserves Cone Photoreceptors in Mouse Models of Retinal Degeneration

    This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by Xi-Qin Ding, Hongwei Ma, Arjun Thapa, Lynsie Morris, T M. Redmond and Wolfgang Baehr. Full size poster available here. Purpose: Cone phototransduction and survival of cones in the human macula is essential for color vision and for […]

    May 5, 2014 — Read more No Comments
  2. Retinitis Pigmentosa 2 Protein Regulates Transport Of Isoprenylated Proteins To Photoreceptor Outer Segments

    This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by Houbin Zhang, Li Jiang, Christin Hanke and Wolfgang Baehr. Full size poster can be downloaded here. Purpose: X-linked retinitis pigmentosa (XLRP) is a devastating form of retinal degeneration, manifesting early in life with symptoms of night blindness, visual […]

    May 4, 2014 — Read more No Comments
  3. Arl3 Rod-Specific Knockout Displays RP-Like Photoreceptor Degeneration

    This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by Christin Hanke, Houbin Zhang, Cecilia D. Gerstner, Jeanne M. Frederick AND Wolfgang Baehr. Full size poster can be downloaded here. Purpose: Arf-like protein 3 (Arl3) localizes predominantly in the photoreceptor inner segment. Germline Arl3 knockout mice do not […]

    May 4, 2014 — Read more No Comments
  4. Moran Eye Center Researcher Wolfgang Baehr: 2014 ARVO Proctor Award Winner

    Webvision is proud to announce that our colleague here at the University of Utah‘s Moran Eye Center researcher Wolfgang Baehr, Ph.D., has been named by the Association for Research in Vision and Ophthalmology (ARVO), as the 2014 recipient of the Proctor Medal —considered to be the highest honor in the world awarded to scientists working in vision research. The award […]

    Apr 17, 2014 — Read more 2 Comments
  5. Dr. Bäerbel Rohrer In Berlin

    My colleague Dr. Wolfgang Baehr at the University of Utah sends this image of friend of Webvision, Dr. Bäerbel Rohrer from Medical University, South Carolina taken last week when they ran into each other in Berlin, Germany. Its always fun to run into friends and colleagues in different parts of the world.  We will look forward to […]

    Apr 11, 2014 — Read more No Comments
  6. The Cilium

    With the exception of a few types of cells, (acinar cells, T lymphocytes and hepatocytes), every cell in your body has a cilia.  In the vision community, we are used to seeing these structures in the distal portion of the photoreceptors.  The reality is that every cell in the retina has a cilium and some cells […]

    Jun 7, 2013 — Read more No Comments
  7. Doctoral Dissertation Defense: Nikko Ronquillo

    Nikko Ronquillo will be defending his dissertation on Wednesday, May 15th at 2:00pm in the Moran Eye Center auditorium on the 1st floor.  Nikko’s dissertation, performed in Wolfgang Baehr’s laboratory is on the Functional and morphological studies of the NPHP5 mouse model: insights into Senior-Løken Syndrome.    

    May 14, 2013 — Read more 1 Comment
  8. February VIG Meeting Announcement

    This is the first Vision Interest Group (VIG) notice here on Webvision.  The VIG is designed as a resource for students and post-docs to present their work/research to their contemporaries and all interested parties who wish to attend and participate. The February VIG at the John A. Moran Eye Center will be held on February […]

    Feb 1, 2013 — Read more No Comments
  9. Who’s That? Wolfgang Baehr

    This photograph of a young scientist in training is the second in the Who’s That? category here on Webvision.  The inaugural post in this category explains the idea behind these posts, but this post shows us, as you’ve deduced from the post title, a young Wolfgang Baehr seen in the Institute for Physical Chemistry at the […]

    Nov 30, 2012 — Read more No Comments
  10. Notable Paper: Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

    Hereditary retinal dystrophies (retinitis pigmentosa, Leber congenital amaurosis, cone-rod dystrophies, macular degeneration) are characterized by loss of visual function, sometimes starting during early childhood, other times in late adulthood.  About 30% of these dystrophies are inherited in an autosomal dominant fashion (RetNet), caused by gain-of-function mutant alleles which encode a malignant form of a normal […]

    Nov 2, 2011 — Read more No Comments
  11. Proliferative reactive gliosis is compatible with glial metabolic support and neuronal function

    This paper by Vazquez-Chona FR, Swan A, Ferrell WD, Jiang L, Baehr W, Chien WM, Fero M, Marc RE and Levine EM addresses a long standing issue in the field of neuroscience: is the reactive phenotype of glial cells in and of itself detrimental to neural survival or function?

    Oct 17, 2011 — Read more No Comments
  12. Retinoid Receptors Trigger Neuritogenesis in Retinal Degenerations

    This paper by Y Lin, BW Jones, A Liu, JF Tucker, K Rapp, L Luo, W Baehr, PS Bernstein, CB Watt, JH Yang, MV Shaw and RE Marc examines the neuronal sprouting or neuritogenesis components of retinal remodeling found in retinal degenerative disease and describes a control process for retinoid X receptors (RXRs) in neuritogenesis. 

    Oct 11, 2011 — Read more 1 Comment
  13. Enzymatic Properties and Regulation of the Native Isozymes of Retinal Membrane Guanylate Cyclase (RetGC) from Mouse Photoreceptors

      This paper is a collaboration with Dr. Wolfgang Baehr and two experts in guanylate cyclase enzymology, Dr. Alexander Dizhoor, and Dr. Kris Palczewski representing a long standing collaboration that has generated over fifty papers going back to 1994.

    Jul 7, 2011 — Read more No Comments
  14. Notable Paper: UNC119 is Required for G Protein Trafficking in Sensory Neurons

      Photoreceptors are specialized cells that elaborate a cilium which becomes the inner and outer segments of the photoreceptor that house photopigments (a beautiful TEM image of a photoreceptor cilium and its inner/outer segment can be seen here)….  

    Jun 14, 2011 — Read more No Comments
  15. Cone Opsin Determines The Time Course of Cone Photoreceptor Degeneration in Leber Congenital Amaurosis

    It is been long known that ventral and central cones degenerate more rapidly than dorsal cones in retinoid-deprived LCA (Leber’s Congenital Amaurosis) models.  This paper in PNAS by Tao Zhang, Wolfgang Baehr…

    Jun 13, 2011 — Read more No Comments
  16. ARVO 2011 Snap Shots

    ARVO 2011 has come and gone.  Its taken me a couple of weeks to get through the post ARVO chaos and get caught up on my own work before posting some of the snapshots, but here they are.  If you’d like to post your snapshots from ARVO here, send me an email (webvision@hsc.utah.edu) and we’ll […]

    May 24, 2011 — Read more 3 Comments