EMT And Myofibroblast Generation In An Injured Lens

Seminar Flyer - Saika

Shizuya Saika, Professor and Chairman of Wakayama Medical University will be delivering a seminar on EMT and myofibroblast generation in an injured lens: modulation of TGFb/Smad signal by extracellular matrix on Tuesday, October 6th at Noon  in the the Moran Eye Center auditorium.

Abstract: EMT and myofibroblast appears in the fibrotic tissues that are undergoing wound healing process. In the eye it is observed in the crystalline lens or other ocular tissues. Transforming growth factor beta (TGFβ)/Smad signal plays a central role in the process of EMT and myofibroblast generation in an injured mouse lens. However, EMT is further modulated by signals derived from binding of extracellular matrix (ECM) to cell surface receptors. In the current talk the mechanisms of modulation of EMT by matricellular proteins, i. e., osteopontin, tenscin-C and lumican through modulation of TGFβ signal. Lacking one of these component suppressed activation of TGFβ signal as revealed by mutant mouse lines. Although overall signals derived from these ECM components support Smad signal and positively modulate EMT, the detailed mechanisms of actions seem differ among each other.

Harris Ripps Memorial At ARVO

Harris Ripps

At this year’s ARVO meeting in Denver, please join us for a session honoring the memory of Dr. Harris Ripps.

Tuesday 1:00 pm – 2:30 pm

Room 708/710/712

Dr. Harris Ripps (1927 – 2014), Proctor Medal winner and past ARVO President, devoted his scientific career to studies on the retina and on causes of visual loss in inherited retinal diseases. He made significant contributions in many areas of vision research, including the kinetics of visual pigment bleaching and regeneration, electrical and chemical communication among retinal neurons and glia, and the cellular mechanisms of retinal degeneration. This memorial session will celebrate Dr. Ripps’ long time vision research career with talks by several his colleagues and students. The audience is welcome to contribute remarks during the open period of the session.

Session chair: John Dowling, Ph.D., Department of Molecular and Cellular Biology, Harvard University

Speakers:

Bradford Ripps, O.D., Total Eyecare, New Jersey
Richard Chappell, Ph.D., Marine Biological Laboratory, Massachusetts
David Pepperberg, Ph.D., Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago
Robert Paul Malchow, Ph.D., Department of Biological Sciences, University of Illinois at Chicago
Haohua Qian, Ph.D., National Eye Institute
Muna Naash, Ph.D., Department of Cell Biology, University of Oklahoma Health Sciences Center
John O’Brien, Ph.D., Department of Ophthalmology and Visual Science, University of Texas
Wen Shen, Ph.D., Department of Biomedical Science, Florida Atlantic University