This poster was presented today at the Association for Research in Vision and Opthalmology (ARVO) meetings in Ft. Lauderdale, Florida by Nathan Gooch, Michael Burr, Bruce Gale and Balamurali Ambati. Full size (almost) poster can be seen here.
Efforts to explore chromosome 10q26, a major candidate region associated with age-related macular degeneration (AMD) have proven difficult and controversial. This particular region of interest is two neighboring genes, ARMS2 and HTRA1. However, efforts in trying to explore the functional involvement of either HTRA1 or ARMS2 in AMD have proven to be difficult and have often yielded conflicting results.