The inward rectifying K+ channels (IRKs) are common ion channels that encompass seven distinct subtypes, each a potential target for pathology or a potential actor in various insults to the nervous system, the retina included. IRKs in the retina are found in Müller glia, retinal pigment epithelium and on neurons in retina, so are fundamental to retinal physiology. However, their function and mechanisms of action have largely been unknown. Continue reading “Notable Paper: Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2”