Efforts to explore chromosome 10q26, a major candidate region associated with age-related macular degeneration (AMD) have proven difficult and controversial. This particular region of interest is two neighboring genes, ARMS2 and HTRA1. However, efforts in trying to explore the functional involvement of either HTRA1 or ARMS2 in AMD have proven to be difficult and have often yielded conflicting results.
This paper is the result of a collaborative effort between Bryan William Jones, Mineo Kondo and Hiroko Terasaki, Carl Watt, Kevin Rapp, James Anderson, Yanhua Lin, Maggie Shaw, Jia-Hui Yang and Robert Marc.
This work presents a substantial advance in models of Retinitis pigmentosa (RP), an set of inherited blinding diseases characterized by progressive loss of retinal photoreceptors. Continue reading “Notable Paper: Retinal Remodeling in the Tg P347L Rabbit, a Large-Eye Model of Retinal Degeneration”