Knockdown of Müller Cell Specific VEGF Reduces Retinal Neovascularization In A Rat Model of Retinopathy of Prematurity

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This abstract was presented today at the Association for Research in Vision and Opthalmology (ARVO) meetings in Seattle, Washington by Yanchao Jiang, Manabu McCloskey, Haibo Wang, Zhihong Yang, Jeremy Strange, Tal Kafir, John G Flannery, Kenneth Greenberg, Scott Hammond and ME Hartnett. Continue reading “Knockdown of Müller Cell Specific VEGF Reduces Retinal Neovascularization In A Rat Model of Retinopathy of Prematurity”

Notable Paper: Increased Expression of Multifunctional Serine Protease, HTRA1, in Retinal Pigment Epithelium Induces Polypoidal Choroidal Vasculopathy

Efforts to explore chromosome 10q26, a major candidate region associated with age-related macular degeneration (AMD) have proven difficult and controversial.  This particular region of interest is two neighboring genes, ARMS2 and HTRA1.  However, efforts in trying to explore the functional involvement of either HTRA1 or ARMS2 in AMD have proven to be difficult and have often yielded conflicting results.

Continue reading “Notable Paper: Increased Expression of Multifunctional Serine Protease, HTRA1, in Retinal Pigment Epithelium Induces Polypoidal Choroidal Vasculopathy”