This manuscript by Clairton F de Souza, Michael Kalloniatis, David L Christie, Philip J Polkinghorne, Charles N J McGhee and Monica L Acosta examines the distribution of creatine transporter in the aging human retina, particularly after retinal detachment. The questions behind this paper have ultimately to do with examining markers of energy metabolism in the retina and any impact on pathology in the retina (and be extension into the brain). Creatine and phosphocreatine are intimately involved with maintenance of ATP levels and are therefore found in high concentrations in tissues that maintain high metabolic loads, like the retina. Creatine is obtained from the diet and maintained in cells with an uptake pump, plasma membrane creatine transporter (CRT) that transports creatine from the blood/serum into the cell. The maintenance of creatine is of fundamental importance in a variety of pathological conditions and as such is an area of hot interest in neuroprotection and supplementation. Continue reading “Interesting Paper: Creatine Transporter Immunolocalization In Aged Human And Detached Retinas”
