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The Evolution of Disease

Lasker 4 month RE_mosaic2_sm

We have another beautiful image (larger size image here) from Gabe Luna in Steve Fisher’s and Geoff Lewis‘ group.  This image representing the evolution of disease post retinal detachment, earned Honorable Mention in the 2013 Olympus Bioscapes International Digital Imaging Competition.

The image is a 60x image using laser scanning confocal image of the murine retinal nerve fiber layer after 2 weeks after retinal detachment.  The ganglion cell axons (red), astrocytes (green), and blood vessels (blue) are labeled using SMI-32, GFAP, and Collagen IV antibodies respectively.

 

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Light-Evoked Synaptic Activity of Retinal Ganglion and Amacrine Cells is Regulated in Developing Mouse Retina

This paper by Q. He, Wang P and Ning Tian characterizes the developmental profiles of the light evoked excitatory and inhibitory synaptic inputs from ON and OFF synaptic pathways in the retina, the light evoked synaptic outputs and the sensitivity of the light evoked synaptic inputs and outputs to light deprivation of retinal ganglion cells (RGCs) and displaced amacrine cells (ACs) of developing mouse retina.  The results strongly suggest that spontaneous and light-evoked synaptic activities of RGCs and ACs are regulated by different synaptic mechanisms.

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