The Organization of the Retina and Visual System
Peter Westenskow from the Friedlander Laboratory at Scripps sends this rather excellent neovascular Santa tuft for everyone to enjoy for Christmas and the New Year. Thanks Peter!
Peter was a star graduate student here at the Moran Eye Center in Sabine Fuhrmann’s laboratory and has done amazing science in his post-doc at Scripps. He’s decided to start looking for his first faculty position, so if you have any spots, give him a shout.
This paper from Toshihide Kurihara, Peter Westenskow, Tim Krohne, Edith Aguilar, Randy A. Johnson, and Marty Friedlander propose a model for the transition from embryonic to adult circulation in the eye using a combinatorial gene deletion approach with over expression assays, examining astrocyte-targeted deletion of von Hippel-Lindau tumor suppressor (Vhl), hypoxia-inducible factor-αs (Hif-αs), and VEGF on normal regression of hyaloid vessels which are transient fetal vessels in the eye that can be seen in the second and early third trimester of human pregnancy. Continue reading “Astrocyte pVHL and HIF-α Isoforms Are Required for Embryonic-To-Adult Vascular Transition In The Eye”
Friend of Webvision, Peter Westenskow in the Friedlander Laboratory sent us this beautiful image of activated Müller glia in a stressed mouse eye. You can see the scar in the photoreceptor layer towards the top of the image. The mouse line is VLDLR -/-. These mice exhibit aberrant neovascular tufts that invade the ONL and eventually grow into the RPE cells. The red staining is pan-cadherin.
Friend of Webvision, Peter Westenskow in Marty Friedlander’s laboratory sent along this gorgeous image of retinal pigment epithelium (RPE) cells differentiating from induced pluripotent stem cells. Continue reading “Retinal Pigment Epithelium Cultures”
ARVO 2011 has come and gone. Its taken me a couple of weeks to get through the post ARVO chaos and get caught up on my own work before posting some of the snapshots, but here they are. If you’d like to post your snapshots from ARVO here, send me an email (webvision@hsc.utah.edu) and we’ll arrange to add them to the list and credit you appropriately.