Peter Westenskow, Research Associate, Department of Cell and Molecular Biology, The Scripps Research Institute Staff Scientist, Lowy Medical Research Institute will be delivering a seminar on Linking Metabolism, Vascular Maintenance, and Photoreceptor Homeostasis in the Retina on Wednesday, July 2nd 15th at Noon in the the Moran Eye Center auditorium.
Abstract: Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina and other CNS tissues. The architecture of the neurosensory retina is a highly organized structure with alternating layers of neurons and blood vessels that match the metabolic demand of neuronal activity with an appropriate supply of oxygen within perfused blood. In my talk I will discuss the importance of retinal neurovascular units in the retina, focusing specifically on work demonstrating that photoreceptors can generate a bioreactive lipid that activates angiogenesis in the choriocapillaris. I hope to provide novel perspectives on the physiology of complex neurovascular units and discuss how these studies may inform future neurotrophic strategies for treating some of the most severe neurodegenerative diseases.
Peter Westenskow from the Friedlander Laboratory at Scripps sends this rather excellent neovascular Santa tuft for everyone to enjoy for Christmas and the New Year. Thanks Peter!
Peter was a star graduate student here at the Moran Eye Center in Sabine Fuhrmann’s laboratory and has done amazing science in his post-doc at Scripps. He’s decided to start looking for his first faculty position, so if you have any spots, give him a shout.
This paper from Toshihide Kurihara, Peter Westenskow, Tim Krohne, Edith Aguilar, Randy A. Johnson, and Marty Friedlander propose a model for the transition from embryonic to adult circulation in the eye using a combinatorial gene deletion approach with over expression assays, examining astrocyte-targeted deletion of von Hippel-Lindau tumor suppressor (Vhl), hypoxia-inducible factor-αs (Hif-αs), and VEGF on normal regression of hyaloid vessels which are transient fetal vessels in the eye that can be seen in the second and early third trimester of human pregnancy. Continue reading “Astrocyte pVHL and HIF-α Isoforms Are Required for Embryonic-To-Adult Vascular Transition In The Eye”
Friend of Webvision, Peter Westenskow in the Friedlander Laboratory sent us this beautiful image of activated Müller glia in a stressed mouse eye. You can see the scar in the photoreceptor layer towards the top of the image. The mouse line is VLDLR -/-. These mice exhibit aberrant neovascular tufts that invade the ONL and eventually grow into the RPE cells. The red staining is pan-cadherin.
Friend of Webvision, Peter Westenskow in Marty Friedlander’s laboratory sent along this gorgeous image of retinal pigment epithelium (RPE) cells differentiating from induced pluripotent stem cells. Continue reading “Retinal Pigment Epithelium Cultures”
ARVO 2011 has come and gone. Its taken me a couple of weeks to get through the post ARVO chaos and get caught up on my own work before posting some of the snapshots, but here they are. If you’d like to post your snapshots from ARVO here, send me an email (firstname.lastname@example.org) and we’ll arrange to add them to the list and credit you appropriately.
Continue reading “ARVO 2011 Snap Shots”