Seminar: Linking Metabolism, Vascular Maintenance, and Photoreceptor Homeostasis in the Retina

Peter W

Peter Westenskow, Research Associate, Department of Cell and Molecular Biology, The Scripps Research Institute Staff Scientist, Lowy Medical Research Institute will be delivering a seminar on Linking Metabolism, Vascular Maintenance, and Photoreceptor Homeostasis in the Retina on Wednesday, July 2nd 15th at Noon  in the the Moran Eye Center auditorium.

Abstract: Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina and other CNS tissues. The architecture of the neurosensory retina is a highly organized structure with alternating layers of neurons and blood vessels that match the metabolic demand of neuronal activity with an appropriate supply of oxygen within perfused blood. In my talk I will discuss the importance of retinal neurovascular units in the retina, focusing specifically on work demonstrating that photoreceptors can generate a bioreactive lipid that activates angiogenesis in the choriocapillaris. I hope to provide novel perspectives on the physiology of complex neurovascular units and discuss how these studies may inform future neurotrophic strategies for treating some of the most severe neurodegenerative diseases.

Merry Christmas From Peter Westenskow And The Friedlander Laboratory

Happy Holidays

Peter Westenskow from the Friedlander Laboratory at Scripps sends this rather excellent neovascular Santa tuft for everyone to enjoy for Christmas and the New Year.  Thanks Peter!

Peter was a star graduate student here at the Moran Eye Center in Sabine Fuhrmann’s laboratory and has done amazing science in his post-doc at Scripps.  He’s decided to start looking for his first faculty position, so if you have any spots, give him a shout.

 

Astrocyte pVHL and HIF-α Isoforms Are Required for Embryonic-To-Adult Vascular Transition In The Eye

This paper from Toshihide Kurihara, Peter Westenskow, Tim Krohne, Edith Aguilar, Randy A. Johnson, and Marty Friedlander propose a model for the transition from embryonic to adult circulation in the eye  using a combinatorial gene deletion approach with over expression assays, examining astrocyte-targeted deletion of von Hippel-Lindau tumor suppressor (Vhl), hypoxia-inducible factor-αs (Hif-αs), and VEGF on normal regression of hyaloid vessels which are transient fetal vessels in the eye that can be seen in the second and early third trimester of human pregnancy.  Continue reading “Astrocyte pVHL and HIF-α Isoforms Are Required for Embryonic-To-Adult Vascular Transition In The Eye”