The Organization of the Retina and Visual System
This *very cool* paper in The Journal of Physiology (also featured in the F1000) by authors Tünde Molnar, Peter Barabas, Lutz Birnbaumer, Claudio Punzo, Vladimir Kefalov and David Krizaj examines mechanisms of cytosolic calcium levels in rod photoreceptor cells.
Continue reading “Store-Operated Channels Regulate Intracellular Calcium In Mammalian Rods”
This is a great review paper on the role of rhodopsin trafficking and its influence on retinal degenerative disease by TJ Hollingsworth and Alecia Gross. Rhodopsin delocalization in rod photoreceptors has been recognized for some time as one of the first indications of retinal photoreceptor cell stress in retinal degenerative diseases, so I was intrigued when seeing this paper come up in PubMed. Continue reading “Review: Defective Trafficking of Rhodopsin and Its Role In Retinal Degenerations”
It is been long known that ventral and central cones degenerate more rapidly than dorsal cones in retinoid-deprived LCA (Leber’s Congenital Amaurosis) models. This paper in PNAS by Tao Zhang, Wolfgang Baehr…
