We have a new Webvision chapter on Retinal Degeneration, Remodeling and Plasticity! Check it out here.
Retinal degenerations are accompanied by retinal remodeling events. These events alter the structure and function of the retina and involve to a large extent, Müller cells which seem to serve as pathways for neuronal migration. This paper by Karin Roesch, Michael B. Stadler and Constance L. Cepko looks at gene expression changes in the Müller cells, one of the glial cells of the retina as the rd1 mouse retina degenerates.
While the paper is not terribly conclusive in its definition of genes or pathways involved, (partially I suspect because of the limited time points examined and the late point in the examinations), this paper does however point in a direction that is useful to the retinal degeneration community. Specifically, Müller cells are fundamentally involved in the remodeling process. Intervening there is an opportunity to arrest or slow down the retinal remodeling process to allow for interventions and understanding which genes are involved is a good first step.
This manuscript by Clairton F de Souza, Michael Kalloniatis, Philip J Polkinghorne, Charles N J McGhee and Monica L Acosta examined retinal remodeling in response to a form of retinal detachment. Rhegmatogenous retinal detachment. The authors describe the changes observed and note that retinal plasticity is acute and likely occurs quickly enough that it may explain persistent vision loss post-reattachment. They also later conclude that retinal detachment, particularly with macular involvement is an emergent condition which is a fundamentally important conclusion.
This paper by Christopher W. Yee, Abduqodir H. Toychiev and Botir T. Sagdullaev examines the role that neural oscillations play in normal and pathological states. In a neurodegenerative model of retinitis pigmentosa, the authors examined the activity of neural networks in the rd1 mouse model and compared that activity to the wild type. Continue reading “Notable Paper: Network Deficiency Exacerbates Impairment in a Mouse Model of Retinal Degeneration”
This paper by Y Lin, BW Jones, A Liu, JF Tucker, K Rapp, L Luo, W Baehr, PS Bernstein, CB Watt, JH Yang, MV Shaw and RE Marc examines the neuronal sprouting or neuritogenesis components of retinal remodeling found in retinal degenerative disease and describes a control process for retinoid X receptors (RXRs) in neuritogenesis. Continue reading “Retinoid Receptors Trigger Neuritogenesis in Retinal Degenerations”
This paper is the result of a collaborative effort between Bryan William Jones, Mineo Kondo and Hiroko Terasaki, Carl Watt, Kevin Rapp, James Anderson, Yanhua Lin, Maggie Shaw, Jia-Hui Yang and Robert Marc.
This work presents a substantial advance in models of Retinitis pigmentosa (RP), an set of inherited blinding diseases characterized by progressive loss of retinal photoreceptors. Continue reading “Notable Paper: Retinal Remodeling in the Tg P347L Rabbit, a Large-Eye Model of Retinal Degeneration”