Seminar: Linking Metabolism, Vascular Maintenance, and Photoreceptor Homeostasis in the Retina

Peter W

Peter Westenskow, Research Associate, Department of Cell and Molecular Biology, The Scripps Research Institute Staff Scientist, Lowy Medical Research Institute will be delivering a seminar on Linking Metabolism, Vascular Maintenance, and Photoreceptor Homeostasis in the Retina on Wednesday, July 2nd 15th at Noon  in the the Moran Eye Center auditorium.

Abstract: Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina and other CNS tissues. The architecture of the neurosensory retina is a highly organized structure with alternating layers of neurons and blood vessels that match the metabolic demand of neuronal activity with an appropriate supply of oxygen within perfused blood. In my talk I will discuss the importance of retinal neurovascular units in the retina, focusing specifically on work demonstrating that photoreceptors can generate a bioreactive lipid that activates angiogenesis in the choriocapillaris. I hope to provide novel perspectives on the physiology of complex neurovascular units and discuss how these studies may inform future neurotrophic strategies for treating some of the most severe neurodegenerative diseases.

Retinal Fundus Images, Ground Truth of Vascular Bifurcations and Crossovers

The vasculature of the eye can provide amazing insight into systemic cardiovascular health.  For those studying the vasculature of the eye as an indicator of pathophysiological states, normative ground truth datasets become critically important.  Recently, George Azzopardi and Nicolai Petkov have made their annotated database of ground truth imagery of vascular bifurcations and crossovers in the retina available here.