Notable Paper: The Molecular Mechanism of Thermal Noise in Rod Photoreceptors

 

Phototransduction is the process by which photon capture by opsins in photoreceptors is transduced into a neural signal.    However, there are limits on visual sensitivity that are imposed by thermal means as opposed to the photochemical mechanisms resulting in activation of the phototransduction cascade.

The mechanism of this limit has long been a matter of debate, however this paper by Samer Gozem, Igor Schapiro, Nicolas Ferré and Massimo Olivucci demonstrates a mechanism.  Mechanistically, the authors examined the maximum absorption wavelength (λmax) and the thermal activation kinetic constant (k) of different visual pigments which indicates that the thermal and photochemical activations are related.  The authors found that rod opsin or rhodopsin possesses a transition state for thermal activation that has the same electronic structure as it does for photo-excitation.  This results in spontaneous and random signals being generated in the rod photoreceptors that impose limits on visual sensitivity.   Continue reading “Notable Paper: The Molecular Mechanism of Thermal Noise in Rod Photoreceptors”

Review: Defective Trafficking of Rhodopsin and Its Role In Retinal Degenerations

This is a great review paper on the role of rhodopsin trafficking and its influence on retinal degenerative disease by TJ Hollingsworth and Alecia Gross.  Rhodopsin delocalization in rod photoreceptors has been recognized for some time as one of the first indications of retinal photoreceptor cell stress in retinal degenerative diseases, so I was intrigued when seeing this paper come up in PubMed.   Continue reading “Review: Defective Trafficking of Rhodopsin and Its Role In Retinal Degenerations”