There is a new publication out in the Journal of Neuroscience (cover story) from Moran Eye Center scientists, Store-Operated Calcium Entry In Müller Glia Is Controlled By Synergistic Activation Of TRPC And Orai Channels authored by Tünde Molnár, Oleg Yarishkin, Peter Barabas, Anthony Iuso, Bryan William Jones, Robert Marc, Tam Phuong, and David Krizaj.
Our colleague and Director of Research at the University of Utah‘s Moran Eye Center, Robert E. Marc, Ph.D. has been named by the International Society for Eye Research as a recipient of the Paul Kayser International Award in Retina Research. The award will be presented to Dr. Marc during the 2014 ISER Biennial Meeting of the Society for Eye Research in San Francisco, California on Thursday, July 24th, 2014.
The Paul Kayser International Award in Retina Research was created by the Directors of Retina Research Foundation and endowed by the Trustees of The Kayser Foundation to honor and perpetuate the memory of long-time friend and dedicated benefactor of RRF, Paul Kayser. Through this award both organizations are demonstrating the conviction they shared with Mr. Kayser that blindness caused by retinal disease is a global concern and must be addressed accordingly. It is thus the purpose of this award to foster greater awareness of the need for intensive study of the retina, its role in the visual process, and the retinal diseases that threaten and/or destroy eyesight by recognizing outstanding achievement and sustaining meritorious scientific investigations worldwide.
Dr. Marc was chosen as the recipient of this award for his lifetime body of work in retinal research, discovering the structure and function of the retina through novel technologies and approaches that have pushed our understanding of the retina forward.
The image that is used for the avatar here on Webvision has been awarded first place in the journal Science and the National Science Foundation‘s Science and Engineering Visualization Challenge for 2011 (video with interviews here).
Merry Christmas and Happy New Year to you from all of us at Webvision. This image, a Christmas wreath created by Robert E. Marc is composed of 104 rod bipolar cell axonal fields from the world’s first complete connectome with synaptic level resolution. Each bipolar cell in this field has been annotated from ultrastructural data revealing its extent and connectivities to other cell classes. The rod bipolar cells have been rendered out in 3D and is viewed from the top, or photoreceptor side, looking down towards the ganglion cell layer.
This paper by Y Lin, BW Jones, A Liu, JF Tucker, K Rapp, L Luo, W Baehr, PS Bernstein, CB Watt, JH Yang, MV Shaw and RE Marc examines the neuronal sprouting or neuritogenesis components of retinal remodeling found in retinal degenerative disease and describes a control process for retinoid X receptors (RXRs) in neuritogenesis. Continue reading “Retinoid Receptors Trigger Neuritogenesis in Retinal Degenerations”
Efforts to explore chromosome 10q26, a major candidate region associated with age-related macular degeneration (AMD) have proven difficult and controversial. This particular region of interest is two neighboring genes, ARMS2 and HTRA1. However, efforts in trying to explore the functional involvement of either HTRA1 or ARMS2 in AMD have proven to be difficult and have often yielded conflicting results.
This paper is the result of a collaborative effort between Bryan William Jones, Mineo Kondo and Hiroko Terasaki, Carl Watt, Kevin Rapp, James Anderson, Yanhua Lin, Maggie Shaw, Jia-Hui Yang and Robert Marc.
This work presents a substantial advance in models of Retinitis pigmentosa (RP), an set of inherited blinding diseases characterized by progressive loss of retinal photoreceptors. Continue reading “Notable Paper: Retinal Remodeling in the Tg P347L Rabbit, a Large-Eye Model of Retinal Degeneration”
A friend of Webvision, renaissance man and photographer extraordinaire, Duncan Davidson visited us at the Moran Eye Center and hung out for a day of science while we performed experiments. Duncan documented some of the work we did that day in the lovely video he posted to Vimeo above. You have quite possibly seen Duncan’s work before on CNN or of individuals giving talks at the TED conference as Duncan is the official TED photographer.
ARVO 2011 has come and gone. Its taken me a couple of weeks to get through the post ARVO chaos and get caught up on my own work before posting some of the snapshots, but here they are. If you’d like to post your snapshots from ARVO here, send me an email (firstname.lastname@example.org) and we’ll arrange to add them to the list and credit you appropriately.