Vogt Koyanagi Harada Syndrome (VKH)


This imagery is from a patient with Vogt Koyanagi Harada Syndrome (VKH).  VKH is a presumed autoimmune disease that presents with waxing and waning subretinal fluid.  There is chromic uveitis with other neurological and dermatological symptoms.  The precise mechanism of the disease is unknown, though it is thought that the autoimmune involvement of melanocytes in the uvea, skin, inner ear and CNS is mediated by  T helper cells.  The fundus photos above show the discoloration of the retina from fluid and the corresponding OCT below, shows the dark areas of fluid infiltration. Fundus photos were made by James Gilman of the Moran Eye Center and taken with a Zeiss FF-450+ and the OCT with with a Zeiss Stratus.