Elevated intraocular pressure (IOP) is the best recognized risk factor for the pathogenesis of glaucoma and the extent of retinal ganglion cell (RGC) degeneration in glaucoma is closely correlated with the extent of IOP elevation. Therefore, accurately and reliably measuring IOP is critical in investigating the mechanism of pressure-induced RGC damage in glaucoma. However, IOP is typically measured under general anesthesia in most studies using mouse models and many anesthetics affect the IOP measurements in both human and animals. Continue reading “Effect of General Anesthetics on IOP in Elevated IOP Mouse Model”
